PAK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0048013Biological processephrin receptor signaling pathway
GO_0000165Biological processMAPK cascade
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_1903608Biological processprotein localization to cytoplasmic stress granule
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0006974Biological processDNA damage response
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0033148Biological processpositive regulation of intracellular estrogen receptor signaling pathway
GO_0006338Biological processchromatin remodeling
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0042060Biological processwound healing
GO_0048812Biological processneuron projection morphogenesis
GO_0060244Biological processnegative regulation of cell proliferation involved in contact inhibition
GO_0030036Biological processactin cytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0006887Biological processexocytosis
GO_0030335Biological processpositive regulation of cell migration
GO_0090063Biological processpositive regulation of microtubule nucleation
GO_0006915Biological processapoptotic process
GO_0048012Biological processhepatocyte growth factor receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0016310Biological processphosphorylation
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0046777Biological processprotein autophosphorylation
GO_0016477Biological processcell migration
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0050770Biological processregulation of axonogenesis
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0030018Cellular componentZ disc
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005884Cellular componentactin filament
GO_0005911Cellular componentcell-cell junction
GO_0005925Cellular componentfocal adhesion
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005694Cellular componentchromosome
GO_0030027Cellular componentlamellipodium
GO_0031965Cellular componentnuclear membrane
GO_0014704Cellular componentintercalated disc
GO_0043015Molecular functiongamma-tubulin binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
P21 (RAC1) activated kinase 1
Synonyms
DescriptionFUNCTION: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes . Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 . Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway . Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes . Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton . Plays a role in the regulation of insulin secretion in response to elevated glucose levels . Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 . Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 . Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus . In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation . In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion . In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling . In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase . Phosphorylates FXR1, promoting its localization to stress granules and activity . .

AccessionsH0YCM0
H0YCG5
ENST00000528203.5
ENST00000533285.1
ENST00000524847.5
E9PRP6
ENST00000528592.5
H0YF55
E9PMP2
ENST00000278568.8 [Q13153-2]
ENST00000529248.5
ENST00000527535.5
ENST00000530617.5
ENST00000527457.5
ENST00000356341.8 [Q13153-1]
E9PM17
Q13153
E9PJF8
E9PQW5
ENST00000528633.1
B3KNX7
ENST00000526968.1
E9PKH9