Name | Number of supported studies | Average coverage | |
---|---|---|---|
conventional dendritic cell | 25 studies | 40% ± 14% | |
mast cell | 17 studies | 25% ± 5% | |
non-classical monocyte | 17 studies | 32% ± 11% | |
macrophage | 17 studies | 27% ± 8% | |
dendritic cell | 16 studies | 43% ± 20% | |
monocyte | 15 studies | 29% ± 10% | |
classical monocyte | 14 studies | 32% ± 12% | |
glutamatergic neuron | 12 studies | 56% ± 23% | |
microglial cell | 10 studies | 30% ± 11% | |
oligodendrocyte | 10 studies | 26% ± 12% | |
GABAergic neuron | 9 studies | 46% ± 21% | |
basal cell | 8 studies | 28% ± 10% | |
oligodendrocyte precursor cell | 8 studies | 23% ± 8% | |
myeloid cell | 8 studies | 33% ± 14% | |
neuron | 6 studies | 35% ± 10% | |
interneuron | 6 studies | 50% ± 22% | |
epithelial cell | 6 studies | 36% ± 14% | |
ciliated cell | 5 studies | 30% ± 8% | |
astrocyte | 5 studies | 29% ± 12% | |
goblet cell | 5 studies | 26% ± 13% | |
mononuclear phagocyte | 4 studies | 30% ± 12% | |
podocyte | 4 studies | 34% ± 12% | |
leukocyte | 4 studies | 23% ± 4% | |
granule cell | 4 studies | 38% ± 13% | |
progenitor cell | 4 studies | 21% ± 4% | |
retinal bipolar neuron | 4 studies | 29% ± 3% | |
endothelial cell | 3 studies | 42% ± 18% | |
GABAergic interneuron | 3 studies | 36% ± 7% | |
club cell | 3 studies | 22% ± 9% | |
amacrine cell | 3 studies | 25% ± 5% | |
retinal cone cell | 3 studies | 24% ± 3% | |
GABAergic amacrine cell | 3 studies | 21% ± 2% | |
OFF-bipolar cell | 3 studies | 30% ± 5% | |
ON-bipolar cell | 3 studies | 23% ± 6% | |
glycinergic amacrine cell | 3 studies | 18% ± 2% | |
rod bipolar cell | 3 studies | 36% ± 6% | |
fibroblast | 3 studies | 20% ± 4% | |
enteroendocrine cell | 3 studies | 20% ± 5% | |
intestinal crypt stem cell | 3 studies | 20% ± 3% | |
transit amplifying cell | 3 studies | 25% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 3783.09 | 966 / 966 | 100% | 54.21 | 527 / 527 |
stomach | 100% | 3360.92 | 359 / 359 | 100% | 50.78 | 286 / 286 |
esophagus | 100% | 3025.46 | 1444 / 1445 | 100% | 51.22 | 183 / 183 |
thymus | 100% | 4306.46 | 653 / 653 | 100% | 56.55 | 604 / 605 |
uterus | 100% | 3005.06 | 170 / 170 | 100% | 40.22 | 458 / 459 |
ovary | 100% | 3342.93 | 180 / 180 | 100% | 41.58 | 428 / 430 |
kidney | 100% | 2664.91 | 89 / 89 | 98% | 28.72 | 887 / 901 |
lung | 98% | 2001.97 | 567 / 578 | 100% | 60.61 | 1151 / 1155 |
bladder | 100% | 3002.33 | 21 / 21 | 97% | 43.52 | 491 / 504 |
skin | 100% | 2283.22 | 1802 / 1809 | 94% | 31.59 | 443 / 472 |
pancreas | 95% | 1662.43 | 312 / 328 | 98% | 47.85 | 175 / 178 |
prostate | 100% | 3137.64 | 245 / 245 | 93% | 22.08 | 465 / 502 |
breast | 93% | 1794.19 | 428 / 459 | 99% | 66.12 | 1110 / 1118 |
brain | 95% | 8458.07 | 2518 / 2642 | 88% | 33.20 | 623 / 705 |
adrenal gland | 96% | 1558.42 | 247 / 258 | 81% | 21.62 | 187 / 230 |
liver | 48% | 526.93 | 108 / 226 | 75% | 15.69 | 305 / 406 |
spleen | 100% | 3210.86 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 45.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.36 | 1 / 1 |
muscle | 99% | 3517.10 | 798 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 9079.04 | 923 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 18.36 | 78 / 80 |
blood vessel | 97% | 1676.20 | 1292 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 36.20 | 28 / 29 |
adipose | 93% | 1449.61 | 1120 / 1204 | 0% | 0 | 0 / 0 |
heart | 48% | 619.70 | 411 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0043507 | Biological process | positive regulation of JUN kinase activity |
GO_0048013 | Biological process | ephrin receptor signaling pathway |
GO_0000165 | Biological process | MAPK cascade |
GO_0048754 | Biological process | branching morphogenesis of an epithelial tube |
GO_0051496 | Biological process | positive regulation of stress fiber assembly |
GO_1903608 | Biological process | protein localization to cytoplasmic stress granule |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_0006974 | Biological process | DNA damage response |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0033148 | Biological process | positive regulation of intracellular estrogen receptor signaling pathway |
GO_0006338 | Biological process | chromatin remodeling |
GO_0031116 | Biological process | positive regulation of microtubule polymerization |
GO_0002223 | Biological process | stimulatory C-type lectin receptor signaling pathway |
GO_0042060 | Biological process | wound healing |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0060244 | Biological process | negative regulation of cell proliferation involved in contact inhibition |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006887 | Biological process | exocytosis |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0090063 | Biological process | positive regulation of microtubule nucleation |
GO_0006915 | Biological process | apoptotic process |
GO_0048012 | Biological process | hepatocyte growth factor receptor signaling pathway |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0016310 | Biological process | phosphorylation |
GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
GO_0006468 | Biological process | protein phosphorylation |
GO_0043408 | Biological process | regulation of MAPK cascade |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0016477 | Biological process | cell migration |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0050770 | Biological process | regulation of axonogenesis |
GO_0001726 | Cellular component | ruffle |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0030018 | Cellular component | Z disc |
GO_0005813 | Cellular component | centrosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005884 | Cellular component | actin filament |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005925 | Cellular component | focal adhesion |
GO_0030425 | Cellular component | dendrite |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005694 | Cellular component | chromosome |
GO_0030027 | Cellular component | lamellipodium |
GO_0031965 | Cellular component | nuclear membrane |
GO_0014704 | Cellular component | intercalated disc |
GO_0043015 | Molecular function | gamma-tubulin binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005518 | Molecular function | collagen binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PAK1 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) P21 (RAC1) activated kinase 1 |
Synonyms | |
Description | FUNCTION: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes . Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 . Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway . Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes . Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton . Plays a role in the regulation of insulin secretion in response to elevated glucose levels . Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 . Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 . Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus . In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation . In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion . In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling . In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase . Phosphorylates FXR1, promoting its localization to stress granules and activity . . |
Accessions | H0YCM0 H0YCG5 ENST00000528203.5 ENST00000533285.1 ENST00000524847.5 E9PRP6 ENST00000528592.5 H0YF55 E9PMP2 ENST00000278568.8 [Q13153-2] ENST00000529248.5 ENST00000527535.5 ENST00000530617.5 ENST00000527457.5 ENST00000356341.8 [Q13153-1] E9PM17 Q13153 E9PJF8 E9PQW5 ENST00000528633.1 B3KNX7 ENST00000526968.1 E9PKH9 |