PLVAP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLVAP at tissue level.

III. Associated gene sets

GO_0043114Biological processregulation of vascular permeability
GO_0070528Biological processprotein kinase C signaling
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0000165Biological processMAPK cascade
GO_0032502Biological processdevelopmental process
GO_0002693Biological processpositive regulation of cellular extravasation
GO_0009986Cellular componentcell surface
GO_0070062Cellular componentextracellular exosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005901Cellular componentcaveola
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene namePLVAP
Protein namePlasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)
Plasmalemma vesicle associated protein
SynonymsFELS
PV1
DescriptionFUNCTION: Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. .

AccessionsM0QXT5
ENST00000595816.1
ENST00000252590.9
M0R310
Q9BX97
ENST00000599426.1