SHANK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048170Biological processpositive regulation of long-term neuronal synaptic plasticity
GO_1900271Biological processregulation of long-term synaptic potentiation
GO_0021773Biological processstriatal medium spiny neuron differentiation
GO_0042297Biological processvocal learning
GO_0000165Biological processMAPK cascade
GO_0007612Biological processlearning
GO_0060997Biological processdendritic spine morphogenesis
GO_1900452Biological processregulation of long-term synaptic depression
GO_0097113Biological processAMPA glutamate receptor clustering
GO_0050885Biological processneuromuscular process controlling balance
GO_0097114Biological processNMDA glutamate receptor clustering
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0071625Biological processvocalization behavior
GO_0051835Biological processpositive regulation of synapse structural plasticity
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_1900451Biological processpositive regulation of glutamate receptor signaling pathway
GO_0060999Biological processpositive regulation of dendritic spine development
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0030534Biological processadult behavior
GO_0007613Biological processmemory
GO_0048854Biological processbrain morphogenesis
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0097117Biological processguanylate kinase-associated protein clustering
GO_0007416Biological processsynapse assembly
GO_0035176Biological processsocial behavior
GO_0032232Biological processnegative regulation of actin filament bundle assembly
GO_0045794Biological processnegative regulation of cell volume
GO_0097107Biological processpostsynaptic density assembly
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0044309Cellular componentneuron spine
GO_0043005Cellular componentneuron projection
GO_0060170Cellular componentciliary membrane
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0045211Cellular componentpostsynaptic membrane
GO_0030160Molecular functionsynaptic receptor adaptor activity
GO_0097110Molecular functionscaffold protein binding
GO_0008270Molecular functionzinc ion binding
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSHANK3
Protein nameSH3 and multiple ankyrin repeat domain 3
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
SHANK3 protein
SHANK3
SH3 and multiple ankyrin repeat domains 3
SynonymsPROSAP2
PSAP2
KIAA1650
DescriptionFUNCTION: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. .

AccessionsF8TCV2
Q9BYB0
A0A0U1RQS4
A0A590UJY5
ENST00000659388.1
A0A669KBA8
Q3S3B4
ENST00000262795.7
ENST00000445220.7
ENST00000673995.1
A0A669K9V7
F8TCV3
A0A0U1RR93
ENST00000664402.2
F8TCV1
ENST00000692848.1
A0A8I5KZC4
ENST00000673971.2
A0A590UJL3
Q6P5A2