MYC | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	24 studies	35% ± 14%	Explore
B cell	22 studies	23% ± 5%	Explore
pericyte	19 studies	40% ± 18%	Explore
smooth muscle cell	19 studies	34% ± 16%	Explore
endothelial cell	18 studies	28% ± 11%	Explore
basal cell	18 studies	37% ± 17%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 7%	Explore
memory B cell	13 studies	22% ± 4%	Explore
naive B cell	13 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	11 studies	40% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	33% ± 11%	Explore
epithelial cell	11 studies	28% ± 13%	Explore
endothelial cell of vascular tree	10 studies	40% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	28% ± 11%	Explore
connective tissue cell	9 studies	37% ± 15%	Explore
vein endothelial cell	8 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	6 studies	28% ± 10%	Explore
intestinal crypt stem cell	5 studies	24% ± 4%	Explore
abnormal cell	5 studies	32% ± 11%	Explore
erythroblast	5 studies	41% ± 10%	Explore
endothelial cell of artery	5 studies	25% ± 7%	Explore
T cell	4 studies	21% ± 4%	Explore
myofibroblast cell	4 studies	34% ± 16%	Explore
adventitial cell	4 studies	36% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 13%	Explore
keratinocyte	4 studies	45% ± 23%	Explore
secretory cell	4 studies	25% ± 9%	Explore
mucosal invariant T cell	4 studies	25% ± 4%	Explore
hematopoietic precursor cell	3 studies	26% ± 3%	Explore
natural killer cell	3 studies	24% ± 5%	Explore
hematopoietic stem cell	3 studies	22% ± 6%	Explore
immature B cell	3 studies	29% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 18%	Explore
T follicular helper cell	3 studies	33% ± 9%	Explore
erythrocyte	3 studies	45% ± 21%	Explore
T-helper 1 cell	3 studies	22% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	25% ± 5%	Explore
regulatory T cell	3 studies	27% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	50% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	20% ± 5%	Explore
lung	5 studies	19% ± 3%	Explore
uterus	5 studies	33% ± 5%	Explore
breast	4 studies	33% ± 11%	Explore
esophagus	3 studies	31% ± 11%	Explore
prostate	3 studies	45% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	19587.62	1809 / 1809	94%	103.55	445 / 472
ovary	98%	9271.22	177 / 180	93%	85.05	398 / 430
esophagus	92%	6212.36	1330 / 1445	98%	110.10	179 / 183
breast	100%	12142.51	459 / 459	88%	69.45	980 / 1118
intestine	87%	5294.17	836 / 966	98%	154.53	516 / 527
stomach	82%	5792.94	294 / 359	98%	139.77	280 / 286
pancreas	90%	4500.89	296 / 328	88%	44.54	157 / 178
uterus	92%	4835.37	156 / 170	84%	76.57	384 / 459
lung	85%	4643.33	491 / 578	90%	72.07	1038 / 1155
prostate	76%	3181.53	187 / 245	95%	74.89	475 / 502
bladder	90%	4637.76	19 / 21	80%	90.59	402 / 504
adrenal gland	97%	4381.14	249 / 258	30%	12.32	69 / 230
kidney	31%	1217.29	28 / 89	79%	50.62	715 / 901
thymus	74%	2605.52	482 / 653	32%	17.16	194 / 605
ureter	0%	0	0 / 0	100%	21.50	1 / 1
adipose	100%	16849.26	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	134.17	79 / 80
spleen	98%	6374.12	237 / 241	0%	0	0 / 0
liver	41%	1635.79	93 / 226	57%	25.98	230 / 406
tonsil	0%	0	0 / 0	96%	89.82	43 / 45
lymph node	0%	0	0 / 0	93%	68.08	27 / 29
brain	0%	10.03	13 / 2642	80%	36.71	563 / 705
blood vessel	69%	3722.82	921 / 1335	0%	0	0 / 0
muscle	58%	2531.28	463 / 803	0%	0	0 / 0
heart	52%	2174.53	451 / 861	0%	0	0 / 0
peripheral blood	40%	3949.19	372 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010468	Biological process	regulation of gene expression
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0090096	Biological process	positive regulation of metanephric cap mesenchymal cell proliferation
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0032204	Biological process	regulation of telomere maintenance
GO_0000165	Biological process	MAPK cascade
GO_0034644	Biological process	cellular response to UV
GO_1904672	Biological process	regulation of somatic stem cell population maintenance
GO_0010332	Biological process	response to gamma radiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0010628	Biological process	positive regulation of gene expression
GO_0006974	Biological process	DNA damage response
GO_0051782	Biological process	negative regulation of cell division
GO_0071456	Biological process	cellular response to hypoxia
GO_1902255	Biological process	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO_0044027	Biological process	negative regulation of gene expression via chromosomal CpG island methylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0032873	Biological process	negative regulation of stress-activated MAPK cascade
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0060633	Biological process	negative regulation of transcription initiation by RNA polymerase II
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0051276	Biological process	chromosome organization
GO_0010564	Biological process	regulation of cell cycle process
GO_0045656	Biological process	negative regulation of monocyte differentiation
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0051973	Biological process	positive regulation of telomerase activity
GO_0032986	Biological process	protein-DNA complex disassembly
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0044346	Biological process	fibroblast apoptotic process
GO_0070848	Biological process	response to growth factor
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0090571	Cellular component	RNA polymerase II transcription repressor complex
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0071943	Cellular component	Myc-Max complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001046	Molecular function	core promoter sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0044877	Molecular function	protein-containing complex binding
GO_0001221	Molecular function	transcription coregulator binding
GO_0042802	Molecular function	identical protein binding
GO_1905761	Molecular function	SCF ubiquitin ligase complex binding
GO_0070888	Molecular function	E-box binding
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MYC
Protein name	Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) Myc protein MYC proto-oncogene, bHLH transcription factor (Myc-related translation/localization regulatory factor) (ORF 114) MYC proto-oncogene, bHLH transcription factor (Myc protein) (ORF 118) MYC proto-oncogene, bHLH transcription factor C-myc protein MYC proto-oncogene, bHLH transcription factor (V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_b) Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) V-myc myelocytomatosis viral oncogene homolog
Synonyms	BHLHE39 hCG_15917 MRTL
Description	FUNCTION: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' . Activates the transcription of growth-related genes . Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis . Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform . .
Accessions	B3CJB8 B3CJD6 ENST00000652288.1 [P01106-1] B3CJ72 B3CJC0 ENST00000707115.1 [P01106-1] Q14899 B3CJ63 B3CJA7 B3CJB9 B3CJC7 B3CJE0 B0B0N9 H0YBG3 ENST00000707114.1 [P01106-1] B3CJ93 B3CJA3 A0A494C1T8 B3CJ94 B3CJ78 B3CJD3 B3CJ74 B3CJ73 B3CJD8 B3CJB3 B3CJC6 B3CJ77 B3CJB1 ENST00000259523.10 B3CJD5 ENST00000707113.1 [P01106-1] B3CJ66 B3CJ89 ENST00000377970.6 [P01106-1] B3CJ90 B3CJ75 B3CJ65 B3CJ64 B3CJ88 B3CJ69 B3CJC8 B3CJD2 Q16591 B3CJ82 B3CJB0 B3CJB2 B3CJ92 ENST00000524013.2 [P01106-3] B3CJ81 B3CJD7 B3CJA8 B3CJ76 B3CJ91 B3CJA4 P01106 ENST00000621592.8 [P01106-2] A0A0B4J1R1 ENST00000641036.1 B3CJD1 B3CJ86 ENST00000641252.1 B3CJ87 B3CJD9 Q14901 B3CJA9 B3CJ71 ENST00000517291.2 B3CJA1 ENST00000707116.1 [P01106-1] ENST00000651626.1 A0A224B085 A0N2G3

MYC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review