Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 23 studies | 26% ± 12% | |
classical monocyte | 17 studies | 27% ± 11% | |
non-classical monocyte | 16 studies | 32% ± 14% | |
macrophage | 16 studies | 31% ± 16% | |
endothelial cell | 13 studies | 27% ± 10% | |
oligodendrocyte precursor cell | 12 studies | 44% ± 15% | |
monocyte | 12 studies | 31% ± 14% | |
memory B cell | 12 studies | 20% ± 4% | |
endothelial cell of lymphatic vessel | 11 studies | 38% ± 21% | |
naive B cell | 11 studies | 19% ± 3% | |
microglial cell | 11 studies | 33% ± 12% | |
myeloid cell | 8 studies | 29% ± 7% | |
dendritic cell | 8 studies | 31% ± 10% | |
CD4-positive, alpha-beta T cell | 5 studies | 21% ± 6% | |
epithelial cell | 5 studies | 37% ± 21% | |
basal cell | 5 studies | 28% ± 16% | |
GABAergic neuron | 4 studies | 33% ± 10% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
astrocyte | 4 studies | 23% ± 7% | |
retinal cone cell | 4 studies | 27% ± 13% | |
mononuclear phagocyte | 4 studies | 22% ± 4% | |
retinal rod cell | 4 studies | 31% ± 13% | |
regulatory T cell | 4 studies | 22% ± 3% | |
glutamatergic neuron | 4 studies | 28% ± 11% | |
mast cell | 4 studies | 22% ± 5% | |
abnormal cell | 3 studies | 23% ± 6% | |
plasma cell | 3 studies | 28% ± 5% | |
adipocyte | 3 studies | 18% ± 1% | |
ciliated cell | 3 studies | 21% ± 7% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 22% ± 4% | |
alveolar macrophage | 3 studies | 34% ± 13% | |
fibroblast | 3 studies | 21% ± 3% | |
immature B cell | 3 studies | 20% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 4275.35 | 459 / 459 | 98% | 50.02 | 1099 / 1118 |
thymus | 100% | 4427.40 | 653 / 653 | 98% | 56.17 | 592 / 605 |
lung | 100% | 2415.91 | 576 / 578 | 95% | 16.20 | 1099 / 1155 |
kidney | 99% | 1994.90 | 88 / 89 | 94% | 24.09 | 850 / 901 |
esophagus | 96% | 1792.41 | 1382 / 1445 | 97% | 21.31 | 178 / 183 |
ovary | 100% | 1689.64 | 180 / 180 | 91% | 15.07 | 391 / 430 |
pancreas | 99% | 1543.22 | 324 / 328 | 90% | 15.43 | 160 / 178 |
skin | 94% | 4711.93 | 1707 / 1809 | 91% | 28.38 | 431 / 472 |
uterus | 98% | 1423.50 | 167 / 170 | 87% | 16.10 | 400 / 459 |
stomach | 92% | 988.38 | 332 / 359 | 89% | 14.14 | 254 / 286 |
prostate | 100% | 1632.49 | 244 / 245 | 79% | 9.95 | 396 / 502 |
intestine | 93% | 1485.50 | 901 / 966 | 83% | 11.13 | 440 / 527 |
bladder | 95% | 1125.86 | 20 / 21 | 77% | 10.58 | 387 / 504 |
brain | 70% | 549.66 | 1840 / 2642 | 81% | 12.23 | 574 / 705 |
adrenal gland | 95% | 1071.45 | 245 / 258 | 54% | 5.72 | 125 / 230 |
liver | 77% | 582.46 | 173 / 226 | 49% | 7.34 | 200 / 406 |
spleen | 100% | 4638.09 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 1726.43 | 1195 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 2705.34 | 876 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 20.18 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 90% | 17.34 | 26 / 29 |
blood vessel | 78% | 728.00 | 1039 / 1335 | 0% | 0 | 0 / 0 |
heart | 68% | 530.09 | 583 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 41% | 4.40 | 33 / 80 |
muscle | 22% | 138.35 | 177 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006468 | Biological process | protein phosphorylation |
GO_0038095 | Biological process | Fc-epsilon receptor signaling pathway |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0000165 | Biological process | MAPK cascade |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0004709 | Molecular function | MAP kinase kinase kinase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004672 | Molecular function | protein kinase activity |
Gene name | MAP3K1 |
Protein name | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Alternative protein MAP3K1 |
Synonyms | MAPKKK1 MEKK1 MEKK |
Description | FUNCTION: Component of a protein kinase signal transduction cascade . Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 . May phosphorylate the MAPK8/JNK1 kinase . Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway . . |
Accessions | L8ECC8 Q13233 ENST00000399503.4 |