MAP3K1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0000165Biological processMAPK cascade
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameMAP3K1
Protein nameMitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Alternative protein MAP3K1
SynonymsMAPKKK1
MEKK1
MEKK
DescriptionFUNCTION: Component of a protein kinase signal transduction cascade . Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 . May phosphorylate the MAPK8/JNK1 kinase . Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway . .

AccessionsL8ECC8
Q13233
ENST00000399503.4