MAPKAPK5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007265Biological processRas protein signal transduction
GO_1904355Biological processpositive regulation of telomere capping
GO_0000165Biological processMAPK cascade
GO_0007165Biological processsignal transduction
GO_0032007Biological processnegative regulation of TOR signaling
GO_0090400Biological processstress-induced premature senescence
GO_0006417Biological processregulation of translation
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0051973Biological processpositive regulation of telomerase activity
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0090398Biological processcellular senescence
GO_0046777Biological processprotein autophosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0032156Cellular componentseptin cytoskeleton
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0009931Molecular functioncalcium-dependent protein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAPKAPK5
Protein nameMAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
MAPK activated protein kinase 5
SynonymsPRAK
DescriptionFUNCTION: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. .

AccessionsENST00000553053.5
ENST00000550735.7 [Q8IW41-2]
ENST00000549875.1
F8VRP2
R4GN33
Q8IW41
ENST00000547305.1
R4GN93
ENST00000551404.7 [Q8IW41-1]