PTHLH report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTHLH at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0008544Biological processepidermis development
GO_0007565Biological processfemale pregnancy
GO_0007267Biological processcell-cell signaling
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0061182Biological processnegative regulation of chondrocyte development
GO_0046058Biological processcAMP metabolic process
GO_0030282Biological processbone mineralization
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0001501Biological processskeletal system development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032330Biological processregulation of chondrocyte differentiation
GO_0002076Biological processosteoblast development
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0051428Molecular functionpeptide hormone receptor binding
GO_0005179Molecular functionhormone activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTHLH
Protein nameParathyroid hormone-related protein (PTH-rP) (PTHrP) [Cleaved into: Osteostatin]
Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
PTHLH protein
SynonymshCG_37265
PTHRP
DescriptionFUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. .; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption. .

FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. .; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption. .

FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. .; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption. .

FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. .; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption. .

AccessionsP12272
Q15252
F5GZD9
ENST00000542963.1
F5H485
ENST00000534890.1
ENST00000539239.5 [P12272-1]
Q53XY9
ENST00000535992.5 [P12272-2]
ENST00000201015.8 [P12272-2]
ENST00000538310.1 [P12272-3]
ENST00000395872.5 [P12272-1]
ENST00000545234.6 [P12272-1]
ENST00000395868.7 [P12272-2]