IRX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0007498Biological processmesoderm development
GO_0060932Biological processHis-Purkinje system cell differentiation
GO_0003165Biological processPurkinje myocyte development
GO_0003167Biological processatrioventricular bundle cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001656Biological processmetanephros development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903598Biological processpositive regulation of gap junction assembly
GO_0030182Biological processneuron differentiation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0072086Biological processspecification of loop of Henle identity
GO_0048468Biological processcell development
GO_0045666Biological processpositive regulation of neuron differentiation
GO_1901844Biological processregulation of cell communication by electrical coupling involved in cardiac conduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameIRX3
Protein nameIroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3)
Iroquois homeobox 3
IRX3 protein
SynonymsIRXB1
DescriptionFUNCTION: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. .

AccessionsENST00000329734.4
Q8N4G7
J3QR11
P78415
ENST00000558054.1