SPDEF | OmnibusX

Name	Number of supported studies	Average coverage
goblet cell	9 studies	46% ± 13%	Explore
respiratory goblet cell	4 studies	24% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	42% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPDEF at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	97%	13021.33	238 / 245	100%	1306.61	501 / 502
breast	65%	3686.59	298 / 459	84%	363.15	944 / 1118
stomach	76%	2161.11	274 / 359	27%	27.78	78 / 286
ureter	0%	0	0 / 0	100%	46.66	1 / 1
intestine	53%	976.25	515 / 966	31%	39.75	166 / 527
skin	62%	518.88	1130 / 1809	0%	0.15	1 / 472
lung	35%	93.94	205 / 578	27%	31.98	314 / 1155
pancreas	8%	15.55	27 / 328	40%	43.64	72 / 178
uterus	18%	146.01	31 / 170	20%	43.42	92 / 459
brain	38%	58.40	995 / 2642	0%	0	0 / 705
ovary	1%	1.81	2 / 180	30%	38.16	128 / 430
esophagus	10%	68.61	138 / 1445	16%	16.34	30 / 183
bladder	5%	15.81	1 / 21	13%	14.82	67 / 504
adipose	3%	17.82	35 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	4.12	1 / 45
liver	0%	0	0 / 226	2%	3.21	8 / 406
muscle	2%	2.94	15 / 803	0%	0	0 / 0
heart	1%	2.99	10 / 861	0%	0	0 / 0
thymus	1%	1.30	4 / 653	0%	0	0 / 605
blood vessel	1%	2.69	7 / 1335	0%	0	0 / 0
adrenal gland	0%	2.62	1 / 258	0%	0	0 / 230
kidney	0%	0	0 / 89	0%	0.39	3 / 901
peripheral blood	0%	9.71	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

GO_0010455	Biological process	positive regulation of cell fate commitment
GO_0010454	Biological process	negative regulation of cell fate commitment
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0060480	Biological process	lung goblet cell differentiation
GO_0072148	Biological process	epithelial cell fate commitment
GO_0060576	Biological process	intestinal epithelial cell development
GO_0030154	Biological process	cell differentiation
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0002068	Biological process	glandular epithelial cell development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding

Gene name	SPDEF
Protein name	SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)
Synonyms	PDEF PSE
Description	FUNCTION: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. .
Accessions	ENST00000374037.8 [O95238-1] O95238 ENST00000544425.2 [O95238-2]

SPDEF report