TFAP2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TFAP2A at tissue level.

III. Associated gene sets

GO_0003404Biological processoptic vesicle morphogenesis
GO_0007605Biological processsensory perception of sound
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0060349Biological processbone morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0070172Biological processpositive regulation of tooth mineralization
GO_0001822Biological processkidney development
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0021559Biological processtrigeminal nerve development
GO_0060021Biological processroof of mouth development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045595Biological processregulation of cell differentiation
GO_0071281Biological processcellular response to iron ion
GO_0021623Biological processoculomotor nerve formation
GO_0003409Biological processoptic cup structural organization
GO_0042472Biological processinner ear morphogenesis
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0048856Biological processanatomical structure development
GO_0061029Biological processeyelid development in camera-type eye
GO_0030501Biological processpositive regulation of bone mineralization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010842Biological processretina layer formation
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0140536Molecular functionnuclear receptor corepressor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTFAP2A
Protein nameTranscription factor AP-2 alpha
Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
Transcription factor AP-2-alpha (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2)
SynonymshCG_37170
TFAP2
AP2TF
DescriptionFUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. .

AccessionsENST00000461628.5
A0A6E1XE14
ENST00000465858.1
F8WEX2
ENST00000482890.6
H7C5E5
ENST00000466073.5
C9J6N8
ENST00000319516.8 [P05549-6]
H7C4N4
C1K3N0
ENST00000379608.9 [P05549-5]
C9JXZ2
P05549
ENST00000475264.5
ENST00000489805.5
ENST00000379613.10
ENST00000488193.7
F8WDC8
ENST00000498450.3