FBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904628Biological processcellular response to phorbol 13-acetate 12-myristate
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0032869Biological processcellular response to insulin stimulus
GO_0006002Biological processfructose 6-phosphate metabolic process
GO_0006000Biological processfructose metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006111Biological processregulation of gluconeogenesis
GO_0071286Biological processcellular response to magnesium ion
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0097403Biological processcellular response to raffinose
GO_0005986Biological processsucrose biosynthetic process
GO_0045820Biological processnegative regulation of glycolytic process
GO_0071475Biological processcellular hyperosmotic salinity response
GO_0031667Biological processresponse to nutrient levels
GO_0071320Biological processcellular response to cAMP
GO_0030388Biological processfructose 1,6-bisphosphate metabolic process
GO_0071477Biological processcellular hypotonic salinity response
GO_0006094Biological processgluconeogenesis
GO_0016311Biological processdephosphorylation
GO_0030308Biological processnegative regulation of cell growth
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0048029Molecular functionmonosaccharide binding
GO_0016208Molecular functionAMP binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0042132Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBP1
Protein nameFructose-1,6-bisphosphatase 1 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)
Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)
fructose-bisphosphatase (EC 3.1.3.11)
SynonymsFBP
hCG_1640493
DescriptionFUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. .

FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. .

FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. .

AccessionsENST00000648117.1
Q5VZC3
ENST00000375326.9
P09467
Q2TU34
ENST00000415431.5
A0A3B3IUC7
ENST00000414122.1
ENST00000682520.1
A0A804HJK9