Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 38 studies | 31% ± 14% | |
endothelial cell of lymphatic vessel | 16 studies | 36% ± 16% | |
natural killer cell | 12 studies | 28% ± 18% | |
endothelial cell of vascular tree | 12 studies | 29% ± 21% | |
capillary endothelial cell | 11 studies | 27% ± 9% | |
CD16-positive, CD56-dim natural killer cell, human | 8 studies | 24% ± 8% | |
vein endothelial cell | 8 studies | 27% ± 14% | |
endothelial cell of artery | 7 studies | 21% ± 5% | |
basal cell | 7 studies | 35% ± 23% | |
epithelial cell | 6 studies | 36% ± 14% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 21% ± 4% | |
astrocyte | 5 studies | 25% ± 9% | |
lymphocyte | 4 studies | 26% ± 6% | |
fibroblast | 4 studies | 37% ± 29% | |
pericyte | 4 studies | 39% ± 30% | |
goblet cell | 4 studies | 25% ± 14% | |
glomerular endothelial cell | 3 studies | 19% ± 2% | |
ciliated cell | 3 studies | 27% ± 3% | |
GABAergic neuron | 3 studies | 20% ± 3% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 4% | |
transit amplifying cell | 3 studies | 28% ± 14% | |
oligodendrocyte | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2564.96 | 1445 / 1445 | 100% | 73.56 | 183 / 183 |
lung | 100% | 3690.04 | 578 / 578 | 100% | 51.46 | 1153 / 1155 |
ovary | 100% | 1859.79 | 180 / 180 | 100% | 34.09 | 429 / 430 |
prostate | 100% | 2063.56 | 244 / 245 | 100% | 41.21 | 501 / 502 |
uterus | 100% | 2320.95 | 170 / 170 | 99% | 53.05 | 456 / 459 |
breast | 100% | 4011.56 | 459 / 459 | 99% | 56.67 | 1103 / 1118 |
pancreas | 100% | 1927.62 | 328 / 328 | 98% | 41.43 | 175 / 178 |
bladder | 100% | 2108.67 | 21 / 21 | 98% | 47.71 | 494 / 504 |
thymus | 100% | 2747.87 | 653 / 653 | 98% | 30.38 | 592 / 605 |
kidney | 100% | 2619.06 | 89 / 89 | 97% | 37.87 | 875 / 901 |
intestine | 100% | 2535.49 | 966 / 966 | 97% | 40.46 | 511 / 527 |
stomach | 100% | 2139.26 | 359 / 359 | 97% | 39.20 | 277 / 286 |
liver | 100% | 2306.87 | 226 / 226 | 96% | 28.30 | 390 / 406 |
brain | 96% | 1604.68 | 2542 / 2642 | 99% | 45.79 | 701 / 705 |
skin | 100% | 3016.10 | 1808 / 1809 | 90% | 31.71 | 425 / 472 |
adrenal gland | 100% | 2386.37 | 258 / 258 | 89% | 17.59 | 204 / 230 |
adipose | 100% | 4297.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 3128.92 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 62.27 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.52 | 1 / 1 |
blood vessel | 100% | 1761.82 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 1374.24 | 852 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 1050.63 | 789 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 8.08 | 44 / 80 |
peripheral blood | 35% | 467.12 | 325 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 21% | 2.27 | 6 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0071300 | Biological process | cellular response to retinoic acid |
GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
GO_0048013 | Biological process | ephrin receptor signaling pathway |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0043114 | Biological process | regulation of vascular permeability |
GO_0031295 | Biological process | T cell costimulation |
GO_0002862 | Biological process | negative regulation of inflammatory response to antigenic stimulus |
GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
GO_0036211 | Biological process | protein modification process |
GO_0030154 | Biological process | cell differentiation |
GO_0050900 | Biological process | leukocyte migration |
GO_0006468 | Biological process | protein phosphorylation |
GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0010827 | Biological process | regulation of glucose transmembrane transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005884 | Cellular component | actin filament |
GO_0005925 | Cellular component | focal adhesion |
GO_0005829 | Cellular component | cytosol |
GO_0019899 | Molecular function | enzyme binding |
GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0005524 | Molecular function | ATP binding |
GO_0044325 | Molecular function | transmembrane transporter binding |
GO_0005515 | Molecular function | protein binding |
GO_0001784 | Molecular function | phosphotyrosine residue binding |
Gene name | YES1 |
Protein name | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) Alternative protein YES1 Tyrosine-protein kinase (EC 2.7.10.2) |
Synonyms | YES |
Description | FUNCTION: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity . . |
Accessions | ENST00000584307.5 ENST00000577961.5 L8E9B9 P07947 J3QRU1 ENST00000314574.5 |