YES1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0048013Biological processephrin receptor signaling pathway
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045087Biological processinnate immune response
GO_0043114Biological processregulation of vascular permeability
GO_0031295Biological processT cell costimulation
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0036211Biological processprotein modification process
GO_0030154Biological processcell differentiation
GO_0050900Biological processleukocyte migration
GO_0006468Biological processprotein phosphorylation
GO_0036120Biological processcellular response to platelet-derived growth factor stimulus
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010827Biological processregulation of glucose transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0019899Molecular functionenzyme binding
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005524Molecular functionATP binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameYES1
Protein nameTyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Alternative protein YES1
Tyrosine-protein kinase (EC 2.7.10.2)
SynonymsYES
DescriptionFUNCTION: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity . .

AccessionsENST00000584307.5
ENST00000577961.5
L8E9B9
P07947
J3QRU1
ENST00000314574.5