FLRT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FLRT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLRT1 at tissue level.

III. Associated gene sets

GO_1990138Biological processneuron projection extension
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0007155Biological processcell adhesion
GO_0016358Biological processdendrite development
GO_0005911Cellular componentcell-cell junction
GO_0005615Cellular componentextracellular space
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0044306Cellular componentneuron projection terminus
GO_0031410Cellular componentcytoplasmic vesicle
GO_0031012Cellular componentextracellular matrix
GO_0032809Cellular componentneuronal cell body membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005925Cellular componentfocal adhesion
GO_0030674Molecular functionprotein-macromolecule adaptor activity

IV. Literature review

[source]
Gene nameFLRT1
Protein nameLeucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1)
SynonymsUNQ752/PRO1483
DescriptionFUNCTION: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. .

AccessionsENST00000246841.3 [Q9NZU1-2]
ENST00000682287.1 [Q9NZU1-2]
Q9NZU1