Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 5 studies | 39% ± 19% | |
non-classical monocyte | 4 studies | 25% ± 7% | |
classical monocyte | 4 studies | 22% ± 3% | |
kidney loop of Henle epithelial cell | 4 studies | 19% ± 2% | |
basal cell | 4 studies | 25% ± 12% | |
fibroblast | 4 studies | 21% ± 4% | |
pancreatic A cell | 3 studies | 30% ± 8% | |
type B pancreatic cell | 3 studies | 38% ± 12% | |
conventional dendritic cell | 3 studies | 26% ± 2% | |
smooth muscle cell | 3 studies | 17% ± 1% | |
ciliated cell | 3 studies | 27% ± 9% | |
endothelial cell | 3 studies | 21% ± 5% | |
macrophage | 3 studies | 27% ± 7% | |
GABAergic neuron | 3 studies | 24% ± 6% | |
glutamatergic neuron | 3 studies | 32% ± 8% | |
dendritic cell | 3 studies | 33% ± 11% | |
goblet cell | 3 studies | 22% ± 6% | |
intestinal crypt stem cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2338.63 | 1445 / 1445 | 100% | 31.86 | 183 / 183 |
ovary | 100% | 2642.16 | 180 / 180 | 100% | 31.71 | 430 / 430 |
prostate | 100% | 2400.87 | 245 / 245 | 100% | 46.39 | 502 / 502 |
brain | 100% | 2359.99 | 2640 / 2642 | 100% | 50.81 | 705 / 705 |
breast | 100% | 2113.37 | 459 / 459 | 100% | 42.37 | 1117 / 1118 |
lung | 100% | 1777.80 | 577 / 578 | 100% | 32.16 | 1154 / 1155 |
kidney | 100% | 2456.89 | 89 / 89 | 100% | 35.70 | 898 / 901 |
stomach | 100% | 1666.87 | 359 / 359 | 100% | 30.79 | 285 / 286 |
adrenal gland | 100% | 2369.44 | 258 / 258 | 100% | 38.14 | 229 / 230 |
uterus | 100% | 2632.60 | 170 / 170 | 100% | 32.89 | 457 / 459 |
thymus | 100% | 2433.09 | 653 / 653 | 100% | 44.80 | 602 / 605 |
bladder | 100% | 2203.52 | 21 / 21 | 99% | 30.06 | 501 / 504 |
intestine | 100% | 2292.61 | 966 / 966 | 99% | 30.05 | 523 / 527 |
pancreas | 100% | 1103.37 | 327 / 328 | 99% | 31.01 | 177 / 178 |
skin | 100% | 2014.65 | 1808 / 1809 | 98% | 30.26 | 461 / 472 |
liver | 100% | 1028.41 | 226 / 226 | 96% | 15.81 | 388 / 406 |
blood vessel | 100% | 2146.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.23 | 29 / 29 |
spleen | 100% | 1518.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 29.08 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 18.60 | 1 / 1 |
adipose | 100% | 1928.20 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 1242.05 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1263.85 | 833 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 21.03 | 75 / 80 |
peripheral blood | 84% | 1267.00 | 779 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1902414 | Biological process | protein localization to cell junction |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_0008104 | Biological process | protein localization |
GO_1904263 | Biological process | positive regulation of TORC1 signaling |
GO_0032008 | Biological process | positive regulation of TOR signaling |
GO_0038202 | Biological process | TORC1 signaling |
GO_0031902 | Cellular component | late endosome membrane |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005925 | Cellular component | focal adhesion |
GO_0070821 | Cellular component | tertiary granule membrane |
GO_0071986 | Cellular component | Ragulator complex |
GO_1990877 | Cellular component | FNIP-folliculin RagC/D GAP |
GO_0010008 | Cellular component | endosome membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0019209 | Molecular function | kinase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | LAMTOR3 |
Protein name | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) |
Synonyms | MAPKSP1 PRO2783 MAP2K1IP1 |
Description | FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane . Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). . |
Accessions | Q9UHA4 ENST00000499666.7 [Q9UHA4-1] ENST00000226522.8 [Q9UHA4-2] |