Ragulator complex

I. Literature review

[source]
NameRagulator complex
IDGO_0071986
collection_id

Cellular component

Alternative ID

GO:0034448, GO:0034449

Exact synonym

MAPKSP1/ROBLD3/C11orf59 complex, Rag GEF

Description

A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).

Related synonym

EGO complex, EGO-GSE complex, GSE complex, GTPase-containing complex for Gap1p sorting in the endosome

External URL
Genes