Name | Ragulator complex |
ID | GO_0071986 |
collection_id | Cellular component |
Alternative ID | GO:0034448, GO:0034449 |
Exact synonym | MAPKSP1/ROBLD3/C11orf59 complex, Rag GEF |
Description | A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). |
Related synonym | EGO complex, EGO-GSE complex, GSE complex, GTPase-containing complex for Gap1p sorting in the endosome |
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Genes |