LAMTOR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008361Biological processregulation of cell size
GO_0061462Biological processprotein localization to lysosome
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0071230Biological processcellular response to amino acid stimulus
GO_0038202Biological processTORC1 signaling
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005764Cellular componentlysosome
GO_0031902Cellular componentlate endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0071986Cellular componentRagulator complex
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameLAMTOR4
Protein nameRagulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4)
Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
SynonymsC7orf59
DescriptionFUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane . Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . .

AccessionsA0A087WVK8
Q0VGL1
A0A087WVU0
A0A087WWR0
A0A087WXQ3
ENST00000441173.1
ENST00000468582.5
C9JXA7
A0A087WV46
A0A087WT92
ENST00000466498.2
ENST00000341942.10
ENST00000474141.5
ENST00000490633.1
ENST00000473459.5
ENST00000488241.5
ENST00000460732.5