LAMTOR5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0009615Biological processresponse to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0061462Biological processprotein localization to lysosome
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0071230Biological processcellular response to amino acid stimulus
GO_1905636Biological processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO_0008361Biological processregulation of cell size
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0019079Biological processviral genome replication
GO_0032008Biological processpositive regulation of TOR signaling
GO_0038202Biological processTORC1 signaling
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0031902Cellular componentlate endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0071986Cellular componentRagulator complex
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0005765Cellular componentlysosomal membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAMTOR5
Protein nameRagulator complex protein LAMTOR5 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)
Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)
SynonymsHBXIP
XIP
DescriptionFUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane . Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway . .

AccessionsENST00000602858.5
E9PLX3
O43504
A0A8Z5A536
ENST00000474861.6
ENST00000602318.6
ENST00000256644.8
R4GMU8
ENST00000483260.5