SLC38A9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006868Biological processglutamine transport
GO_1903826Biological processL-arginine transmembrane transport
GO_0003333Biological processamino acid transmembrane transport
GO_0071230Biological processcellular response to amino acid stimulus
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0015803Biological processbranched-chain amino acid transport
GO_0006867Biological processasparagine transport
GO_0031902Cellular componentlate endosome membrane
GO_0005764Cellular componentlysosome
GO_0005770Cellular componentlate endosome
GO_0071986Cellular componentRagulator complex
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0005765Cellular componentlysosomal membrane
GO_0061459Molecular functionL-arginine transmembrane transporter activity
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0015485Molecular functioncholesterol binding
GO_0015186Molecular functionL-glutamine transmembrane transporter activity
GO_0032935Molecular functionsterol sensor activity
GO_0034618Molecular functionarginine binding
GO_0046872Molecular functionmetal ion binding
GO_0015182Molecular functionL-asparagine transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015190Molecular functionL-leucine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC38A9
Protein nameSolute carrier family 38 member 9
Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)
Neutral amino acid transporter 9 (Solute carrier family 38 member 9)
SynonymsURLC11
hCG_40989
FLJ90709
DescriptionFUNCTION: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels . Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids . Acts as an arginine sensor . Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation . However, the transport mechanism is not well defined and the role of sodium is not clear . Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC . Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases . Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency . .

AccessionsENST00000396865.7 [Q8NBW4-1]
ENST00000506624.5
Q8NBW4
ENST00000505708.5
ENST00000513993.5
ENST00000507109.5
ENST00000508124.5
ENST00000503891.5
ENST00000513275.5
ENST00000505563.5
D6R9X0
B3KVK8
D6RG31
ENST00000502247.1
D6RIW7
ENST00000512595.5 [Q8NBW4-3]
D6RER8
ENST00000512208.5
ENST00000515629.5 [Q8NBW4-4]
D6RDH2
ENST00000318672.7 [Q8NBW4-1]
D6RE72
ENST00000416547.6
D6R9Q7
D6RBB9
ENST00000511233.5
ENST00000503817.5
D6RHF5
D6RHW0
E7ESU6