Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 11 studies | 33% ± 11% | |
microglial cell | 9 studies | 27% ± 9% | |
endothelial cell | 8 studies | 23% ± 6% | |
GABAergic neuron | 7 studies | 35% ± 18% | |
glutamatergic neuron | 6 studies | 45% ± 22% | |
oligodendrocyte precursor cell | 6 studies | 27% ± 9% | |
macrophage | 6 studies | 32% ± 9% | |
endothelial cell of lymphatic vessel | 5 studies | 23% ± 4% | |
astrocyte | 5 studies | 29% ± 12% | |
interneuron | 5 studies | 35% ± 18% | |
fibroblast | 4 studies | 18% ± 2% | |
type I pneumocyte | 4 studies | 18% ± 5% | |
epithelial cell | 3 studies | 26% ± 14% | |
dendritic cell | 3 studies | 21% ± 2% | |
myeloid cell | 3 studies | 21% ± 5% | |
alveolar macrophage | 3 studies | 24% ± 6% | |
club cell | 3 studies | 25% ± 11% | |
monocyte | 3 studies | 22% ± 2% | |
pericyte | 3 studies | 19% ± 4% | |
adipocyte | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 506.05 | 1445 / 1445 | 100% | 4.47 | 183 / 183 |
breast | 100% | 570.09 | 459 / 459 | 100% | 5.08 | 1116 / 1118 |
brain | 100% | 436.17 | 2636 / 2642 | 100% | 3.99 | 705 / 705 |
liver | 100% | 564.05 | 226 / 226 | 100% | 5.74 | 405 / 406 |
lung | 100% | 536.36 | 576 / 578 | 100% | 5.47 | 1155 / 1155 |
uterus | 100% | 619.36 | 170 / 170 | 100% | 5.06 | 457 / 459 |
bladder | 100% | 506.05 | 21 / 21 | 99% | 4.77 | 501 / 504 |
thymus | 100% | 575.31 | 653 / 653 | 99% | 4.17 | 601 / 605 |
ovary | 100% | 561.76 | 180 / 180 | 99% | 4.05 | 426 / 430 |
pancreas | 100% | 755.70 | 328 / 328 | 99% | 3.89 | 176 / 178 |
intestine | 100% | 538.08 | 966 / 966 | 98% | 4.01 | 519 / 527 |
adrenal gland | 100% | 470.43 | 258 / 258 | 98% | 3.92 | 226 / 230 |
stomach | 100% | 488.60 | 359 / 359 | 98% | 4.35 | 281 / 286 |
prostate | 100% | 521.68 | 245 / 245 | 98% | 3.09 | 492 / 502 |
kidney | 100% | 423.11 | 89 / 89 | 98% | 3.52 | 881 / 901 |
skin | 100% | 636.11 | 1809 / 1809 | 96% | 3.96 | 455 / 472 |
adipose | 100% | 605.93 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 5.05 | 29 / 29 |
spleen | 100% | 711.93 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 5.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.01 | 1 / 1 |
blood vessel | 100% | 423.44 | 1331 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 299.70 | 792 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 231.09 | 839 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 2.49 | 72 / 80 |
peripheral blood | 88% | 342.74 | 818 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006868 | Biological process | glutamine transport |
GO_1903826 | Biological process | L-arginine transmembrane transport |
GO_0003333 | Biological process | amino acid transmembrane transport |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_1904263 | Biological process | positive regulation of TORC1 signaling |
GO_0032008 | Biological process | positive regulation of TOR signaling |
GO_0015803 | Biological process | branched-chain amino acid transport |
GO_0006867 | Biological process | asparagine transport |
GO_0031902 | Cellular component | late endosome membrane |
GO_0005764 | Cellular component | lysosome |
GO_0005770 | Cellular component | late endosome |
GO_0071986 | Cellular component | Ragulator complex |
GO_1990877 | Cellular component | FNIP-folliculin RagC/D GAP |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0061459 | Molecular function | L-arginine transmembrane transporter activity |
GO_0015171 | Molecular function | amino acid transmembrane transporter activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0015179 | Molecular function | L-amino acid transmembrane transporter activity |
GO_0015485 | Molecular function | cholesterol binding |
GO_0015186 | Molecular function | L-glutamine transmembrane transporter activity |
GO_0032935 | Molecular function | sterol sensor activity |
GO_0034618 | Molecular function | arginine binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0015182 | Molecular function | L-asparagine transmembrane transporter activity |
GO_0005515 | Molecular function | protein binding |
GO_0015190 | Molecular function | L-leucine transmembrane transporter activity |
Gene name | SLC38A9 |
Protein name | Solute carrier family 38 member 9 Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) Neutral amino acid transporter 9 (Solute carrier family 38 member 9) |
Synonyms | URLC11 hCG_40989 FLJ90709 |
Description | FUNCTION: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels . Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids . Acts as an arginine sensor . Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation . However, the transport mechanism is not well defined and the role of sodium is not clear . Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC . Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases . Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency . . |
Accessions | ENST00000396865.7 [Q8NBW4-1] ENST00000506624.5 Q8NBW4 ENST00000505708.5 ENST00000513993.5 ENST00000507109.5 ENST00000508124.5 ENST00000503891.5 ENST00000513275.5 ENST00000505563.5 D6R9X0 B3KVK8 D6RG31 ENST00000502247.1 D6RIW7 ENST00000512595.5 [Q8NBW4-3] D6RER8 ENST00000512208.5 ENST00000515629.5 [Q8NBW4-4] D6RDH2 ENST00000318672.7 [Q8NBW4-1] D6RE72 ENST00000416547.6 D6R9Q7 D6RBB9 ENST00000511233.5 ENST00000503817.5 D6RHF5 D6RHW0 E7ESU6 |