LAMTOR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0001558Biological processregulation of cell growth
GO_0001919Biological processregulation of receptor recycling
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0031669Biological processcellular response to nutrient levels
GO_0016197Biological processendosomal transport
GO_0032418Biological processlysosome localization
GO_0060620Biological processregulation of cholesterol import
GO_0007032Biological processendosome organization
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010874Biological processregulation of cholesterol efflux
GO_0008104Biological processprotein localization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0072657Biological processprotein localization to membrane
GO_0150032Biological processpositive regulation of protein localization to lysosome
GO_0038202Biological processTORC1 signaling
GO_0042632Biological processcholesterol homeostasis
GO_0031902Cellular componentlate endosome membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005764Cellular componentlysosome
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0071986Cellular componentRagulator complex
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0005765Cellular componentlysosomal membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0051020Molecular functionGTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAMTOR1
Protein nameRagulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1)
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)
SynonymsPP7157
PDRO
C11orf59
DescriptionFUNCTION: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane . Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane . LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes . Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes . May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes . May also play a role in RHOA activation . .

AccessionsF5H479
ENST00000544594.5
H0YFI1
Q6IAA8
ENST00000535107.5
ENST00000535872.1
ENST00000538404.1
F5GX19
ENST00000545249.5
ENST00000278671.10
F5H267
F5H3Y3