FHL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055015Biological processventricular cardiac muscle cell development
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_0060347Biological processheart trabecula formation
GO_0001649Biological processosteoblast differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009725Biological processresponse to hormone
GO_0043066Biological processnegative regulation of apoptotic process
GO_0055014Biological processatrial cardiac muscle cell development
GO_0030018Cellular componentZ disc
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFHL2
Protein nameFour and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Four-and-a-half LIM domains 2
Uncharacterized protein FHL2
FHL2 protein (Four and a half LIM domains 2) (HCG28013, isoform CRA_a)
Four and a half LIM domains 2
SynonymsSLIM3
DRAL
hCG_28013
DescriptionFUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes . .

AccessionsENST00000322142.13 [Q14192-1]
C9J3S8
ENST00000607522.1
Q14192
ENST00000393353.7 [Q14192-1]
ENST00000408995.5 [Q14192-1]
ENST00000358129.8 [Q14192-2]
U3KQT4
F8WDA8
ENST00000447958.1
Q53T40
Q53QP3
ENST00000344213.9 [Q14192-1]
ENST00000452732.1
ENST00000409177.6 [Q14192-1]
Q6I9R8
ENST00000530340.6 [Q14192-1]
ENST00000393352.7 [Q14192-1]
ENST00000409807.5 [Q14192-1]
I0CE67