ADD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	33% ± 14%	Explore
pericyte	32 studies	29% ± 11%	Explore
natural killer cell	30 studies	23% ± 7%	Explore
fibroblast	29 studies	27% ± 10%	Explore
B cell	23 studies	27% ± 8%	Explore
smooth muscle cell	23 studies	25% ± 7%	Explore
astrocyte	22 studies	43% ± 18%	Explore
endothelial cell of lymphatic vessel	16 studies	34% ± 10%	Explore
oligodendrocyte	16 studies	42% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	23% ± 7%	Explore
capillary endothelial cell	14 studies	28% ± 6%	Explore
naive B cell	13 studies	24% ± 7%	Explore
memory B cell	13 studies	21% ± 8%	Explore
type I pneumocyte	12 studies	31% ± 10%	Explore
endothelial cell of artery	12 studies	35% ± 9%	Explore
microglial cell	12 studies	33% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 15%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 7%	Explore
ciliated cell	11 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	11 studies	19% ± 5%	Explore
myofibroblast cell	11 studies	27% ± 5%	Explore
glutamatergic neuron	11 studies	44% ± 24%	Explore
macrophage	11 studies	30% ± 12%	Explore
T cell	10 studies	20% ± 4%	Explore
connective tissue cell	10 studies	25% ± 6%	Explore
vein endothelial cell	10 studies	26% ± 10%	Explore
epithelial cell	10 studies	32% ± 17%	Explore
gamma-delta T cell	10 studies	22% ± 8%	Explore
GABAergic neuron	9 studies	44% ± 20%	Explore
neuron	9 studies	38% ± 17%	Explore
retinal cone cell	9 studies	56% ± 15%	Explore
retinal rod cell	9 studies	57% ± 18%	Explore
basal cell	9 studies	27% ± 12%	Explore
adipocyte	9 studies	24% ± 6%	Explore
mature NK T cell	8 studies	22% ± 8%	Explore
endothelial cell of vascular tree	8 studies	31% ± 17%	Explore
mast cell	7 studies	21% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
retinal ganglion cell	7 studies	45% ± 23%	Explore
interneuron	7 studies	40% ± 22%	Explore
club cell	7 studies	24% ± 8%	Explore
monocyte	7 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	21% ± 5%	Explore
classical monocyte	6 studies	25% ± 11%	Explore
amacrine cell	6 studies	24% ± 6%	Explore
myeloid cell	6 studies	25% ± 7%	Explore
type II pneumocyte	6 studies	22% ± 6%	Explore
dendritic cell	6 studies	29% ± 16%	Explore
regulatory T cell	6 studies	17% ± 1%	Explore
leukocyte	5 studies	21% ± 6%	Explore
abnormal cell	5 studies	28% ± 10%	Explore
retina horizontal cell	5 studies	27% ± 8%	Explore
lymphocyte	5 studies	34% ± 8%	Explore
Mueller cell	5 studies	51% ± 9%	Explore
secretory cell	4 studies	26% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	25% ± 8%	Explore
hematopoietic precursor cell	4 studies	29% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
non-classical monocyte	4 studies	30% ± 12%	Explore
progenitor cell	4 studies	25% ± 6%	Explore
retinal bipolar neuron	4 studies	22% ± 3%	Explore
granule cell	4 studies	28% ± 3%	Explore
immature B cell	4 studies	29% ± 7%	Explore
respiratory goblet cell	4 studies	22% ± 8%	Explore
enteroendocrine cell	4 studies	24% ± 7%	Explore
goblet cell	4 studies	32% ± 20%	Explore
ionocyte	3 studies	22% ± 3%	Explore
conventional dendritic cell	3 studies	33% ± 18%	Explore
plasmablast	3 studies	37% ± 15%	Explore
glomerular endothelial cell	3 studies	37% ± 7%	Explore
GABAergic interneuron	3 studies	31% ± 6%	Explore
glial cell	3 studies	34% ± 6%	Explore
mucosal invariant T cell	3 studies	21% ± 2%	Explore
plasma cell	3 studies	31% ± 9%	Explore
squamous epithelial cell	3 studies	36% ± 23%	Explore
OFF-bipolar cell	3 studies	29% ± 3%	Explore
ON-bipolar cell	3 studies	28% ± 4%	Explore
rod bipolar cell	3 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	24% ± 10%	Explore
innate lymphoid cell	3 studies	22% ± 1%	Explore
muscle cell	3 studies	34% ± 11%	Explore
ependymal cell	3 studies	42% ± 18%	Explore
adventitial cell	3 studies	22% ± 2%	Explore
alveolar macrophage	3 studies	27% ± 10%	Explore
chondrocyte	3 studies	28% ± 4%	Explore
Schwann cell	3 studies	33% ± 15%	Explore
transit amplifying cell	3 studies	33% ± 21%	Explore
brush cell	3 studies	25% ± 7%	Explore
mesothelial cell	3 studies	27% ± 1%	Explore
cardiac muscle cell	3 studies	18% ± 2%	Explore
epithelial cell of proximal tubule	3 studies	24% ± 5%	Explore
mural cell	3 studies	44% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	40% ± 20%	Explore
lung	14 studies	23% ± 7%	Explore
eye	9 studies	46% ± 15%	Explore
peripheral blood	7 studies	26% ± 12%	Explore
heart	5 studies	22% ± 4%	Explore
kidney	4 studies	19% ± 6%	Explore
liver	4 studies	30% ± 14%	Explore
intestine	4 studies	24% ± 8%	Explore
adipose	4 studies	26% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	19678.40	2642 / 2642	100%	122.01	705 / 705
esophagus	100%	21563.38	1445 / 1445	100%	48.16	183 / 183
ovary	100%	23360.42	180 / 180	100%	43.75	430 / 430
prostate	100%	19095.38	245 / 245	100%	73.97	502 / 502
lung	100%	20094.48	578 / 578	100%	48.87	1154 / 1155
kidney	100%	13939.17	89 / 89	100%	69.83	899 / 901
breast	100%	19108.13	459 / 459	100%	63.97	1115 / 1118
stomach	100%	14373.33	359 / 359	100%	44.59	285 / 286
bladder	100%	23510.86	21 / 21	100%	50.13	502 / 504
skin	100%	14408.72	1808 / 1809	100%	68.57	470 / 472
thymus	100%	16293.07	652 / 653	100%	70.13	603 / 605
intestine	100%	22293.42	966 / 966	99%	45.13	524 / 527
adrenal gland	100%	14169.91	258 / 258	99%	60.74	227 / 230
uterus	100%	23970.29	170 / 170	99%	45.26	453 / 459
pancreas	97%	6660.43	318 / 328	99%	60.42	176 / 178
liver	99%	6236.82	224 / 226	96%	32.88	389 / 406
adipose	100%	20274.94	1204 / 1204	0%	0	0 / 0
blood vessel	100%	27674.89	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	60.01	80 / 80
lymph node	0%	0	0 / 0	100%	44.34	29 / 29
muscle	100%	17065.60	803 / 803	0%	0	0 / 0
spleen	100%	18383.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	42.13	45 / 45
ureter	0%	0	0 / 0	100%	40.33	1 / 1
heart	100%	13918.39	859 / 861	0%	0	0 / 0
peripheral blood	99%	11503.08	916 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051016	Biological process	barbed-end actin filament capping
GO_1903142	Biological process	positive regulation of establishment of endothelial barrier
GO_0032092	Biological process	positive regulation of protein binding
GO_1903393	Biological process	positive regulation of adherens junction organization
GO_0071277	Biological process	cellular response to calcium ion
GO_0051017	Biological process	actin filament bundle assembly
GO_0030036	Biological process	actin cytoskeleton organization
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0016604	Cellular component	nuclear body
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0008290	Cellular component	F-actin capping protein complex
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0030507	Molecular function	spectrin binding
GO_0045296	Molecular function	cadherin binding
GO_0051015	Molecular function	actin filament binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003723	Molecular function	RNA binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005516	Molecular function	calmodulin binding
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	ADD1
Protein name	Adducin 1 Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 protein
Synonyms	ADDA
Description	FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Accessions	E7EV99 ENST00000264758.11 [P35611-3] ENST00000651918.1 [P35611-2] ENST00000511797.5 ENST00000398129.5 [P35611-1] ENST00000683351.1 D6RAH3 ENST00000503455.6 H0YFD8 A0A804HL01 ENST00000508277.5 D6RF25 H0Y9H2 Q96D30 ENST00000541843.2 E7ENY0 ENST00000355842.7 [P35611-4] D6RJE2 ENST00000513328.6 P35611 ENST00000514940.5 ENST00000536424.2 H0YG19 ENST00000398123.6 [P35611-6] ENST00000398125.5 [P35611-6] ENST00000510101.5

ADD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review