EFNB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	33% ± 14%	Explore
endothelial cell of artery	15 studies	53% ± 18%	Explore
endothelial cell of lymphatic vessel	12 studies	28% ± 8%	Explore
capillary endothelial cell	12 studies	28% ± 5%	Explore
endothelial cell of vascular tree	11 studies	25% ± 15%	Explore
vein endothelial cell	7 studies	25% ± 11%	Explore
epithelial cell	7 studies	27% ± 8%	Explore
fibroblast	5 studies	23% ± 8%	Explore
glomerular endothelial cell	4 studies	40% ± 4%	Explore
astrocyte	4 studies	22% ± 4%	Explore
goblet cell	4 studies	28% ± 18%	Explore
mesothelial cell	3 studies	30% ± 12%	Explore
GABAergic neuron	3 studies	28% ± 7%	Explore
glutamatergic neuron	3 studies	42% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	30% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3667.98	966 / 966	99%	40.90	524 / 527
prostate	100%	3011.71	245 / 245	99%	34.65	498 / 502
esophagus	100%	2110.87	1444 / 1445	98%	41.12	180 / 183
stomach	99%	2066.72	356 / 359	99%	36.01	283 / 286
thymus	100%	2910.40	652 / 653	96%	19.80	582 / 605
lung	100%	5392.25	578 / 578	93%	21.31	1072 / 1155
bladder	100%	1478.62	21 / 21	92%	25.67	465 / 504
uterus	100%	2293.76	170 / 170	89%	20.65	408 / 459
breast	100%	3978.70	459 / 459	88%	14.39	985 / 1118
kidney	100%	2152.39	89 / 89	87%	26.62	780 / 901
ovary	79%	1519.09	142 / 180	95%	26.94	407 / 430
adrenal gland	97%	1283.12	251 / 258	71%	10.58	164 / 230
brain	97%	1777.13	2575 / 2642	67%	10.31	474 / 705
pancreas	45%	345.77	148 / 328	98%	33.54	174 / 178
skin	94%	2908.35	1698 / 1809	36%	5.42	169 / 472
adipose	100%	4182.33	1204 / 1204	0%	0	0 / 0
spleen	100%	1675.35	241 / 241	0%	0	0 / 0
blood vessel	100%	2461.07	1331 / 1335	0%	0	0 / 0
heart	99%	1728.59	849 / 861	0%	0	0 / 0
liver	49%	438.98	110 / 226	40%	3.85	163 / 406
muscle	88%	776.32	706 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	14.61	38 / 45
lymph node	0%	0	0 / 0	24%	1.87	7 / 29
eye	0%	0	0 / 0	1%	0.07	1 / 80
peripheral blood	1%	4.01	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034332	Biological process	adherens junction organization
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0009887	Biological process	animal organ morphogenesis
GO_0002042	Biological process	cell migration involved in sprouting angiogenesis
GO_0031295	Biological process	T cell costimulation
GO_2000727	Biological process	positive regulation of cardiac muscle cell differentiation
GO_0007155	Biological process	cell adhesion
GO_0099072	Biological process	regulation of postsynaptic membrane neurotransmitter receptor levels
GO_0007267	Biological process	cell-cell signaling
GO_0010839	Biological process	negative regulation of keratinocyte proliferation
GO_0046718	Biological process	symbiont entry into host cell
GO_0010977	Biological process	negative regulation of neuron projection development
GO_1903849	Biological process	positive regulation of aorta morphogenesis
GO_0050920	Biological process	regulation of chemotaxis
GO_0099149	Biological process	regulation of postsynaptic neurotransmitter receptor internalization
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0072178	Biological process	nephric duct morphogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0048514	Biological process	blood vessel morphogenesis
GO_0001945	Biological process	lymph vessel development
GO_0048845	Biological process	venous blood vessel morphogenesis
GO_0043616	Biological process	keratinocyte proliferation
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0005925	Cellular component	focal adhesion
GO_0005912	Cellular component	adherens junction
GO_0046875	Molecular function	ephrin receptor binding
GO_0001618	Molecular function	virus receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EFNB2
Protein name	Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) Ephrin-B2
Synonyms	HTKL LERK5 EPLG5
Description	FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. .; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. .
Accessions	P52799 Q2PDH7 ENST00000646441.1

EFNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review