HNRNPK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006396Biological processRNA processing
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0010988Biological processregulation of low-density lipoprotein particle clearance
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_1902165Biological processregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_1905599Biological processpositive regulation of low-density lipoprotein receptor activity
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0002102Cellular componentpodosome
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_1990904Cellular componentribonucleoprotein complex
GO_0000785Cellular componentchromatin
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHNRNPK
Protein nameHeterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Heterogeneous nuclear ribonucleoprotein K
SynonymsHNRPK
DescriptionFUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation . .

AccessionsENST00000704013.1
ENST00000704004.1 [P61978-3]
ENST00000704059.1 [P61978-2]
ENST00000457156.6
ENST00000704054.1
ENST00000704051.1 [P61978-1]
ENST00000704056.1
S4R359
A0A994J6T5
ENST00000704010.1
S4R457
ENST00000704006.1 [P61978-1]
ENST00000704016.1
ENST00000704009.1
A0A994J4U9
B4DUQ1
ENST00000704005.1 [P61978-2]
ENST00000481820.6
ENST00000376281.8 [P61978-2]
ENST00000472778.6
ENST00000376263.8 [P61978-2]
A0A994J4S7
ENST00000457156.6 [P61978-3]
ENST00000704057.1 [P61978-2]
ENST00000704008.1
ENST00000704052.1 [P61978-1]
ENST00000704053.1 [P61978-1]
ENST00000704060.1
ENST00000704015.1
P61978
A0A994J795
ENST00000704055.1
ENST00000704007.1
ENST00000360384.9 [P61978-1]
A0A994J6U9
Q5T6W2
ENST00000704012.1
ENST00000704011.1 [P61978-2]
A0A994J4E9
A0A994J782
ENST00000704014.1
ENST00000704058.1 [P61978-1]
ENST00000351839.7 [P61978-1]