FLRT3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLRT3 at tissue level.

III. Associated gene sets

GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0003345Biological processproepicardium cell migration involved in pericardium morphogenesis
GO_0060322Biological processhead development
GO_0007507Biological processheart development
GO_0031175Biological processneuron projection development
GO_0048678Biological processresponse to axon injury
GO_0099560Biological processsynaptic membrane adhesion
GO_0050919Biological processnegative chemotaxis
GO_0048598Biological processembryonic morphogenesis
GO_1990138Biological processneuron projection extension
GO_0007416Biological processsynapse assembly
GO_0051965Biological processpositive regulation of synapse assembly
GO_0007411Biological processaxon guidance
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097060Cellular componentsynaptic membrane
GO_0043679Cellular componentaxon terminus
GO_0031012Cellular componentextracellular matrix
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0044295Cellular componentaxonal growth cone
GO_0045211Cellular componentpostsynaptic membrane
GO_0030054Cellular componentcell junction
GO_0032584Cellular componentgrowth cone membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0045499Molecular functionchemorepellent activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFLRT3
Protein nameLeucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)
SynonymsUNQ856/PRO1865
KIAA1469
DescriptionFUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells . Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) . Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). .

AccessionsENST00000378053.3
Q9NZU0
ENST00000341420.5