Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 26 studies | 48% ± 18% | |
smooth muscle cell | 25 studies | 52% ± 24% | |
fibroblast | 22 studies | 29% ± 11% | |
myofibroblast cell | 14 studies | 51% ± 21% | |
endothelial cell | 11 studies | 26% ± 10% | |
connective tissue cell | 8 studies | 45% ± 11% | |
capillary endothelial cell | 5 studies | 25% ± 13% | |
endothelial cell of artery | 4 studies | 21% ± 5% | |
endothelial cell of vascular tree | 4 studies | 23% ± 7% | |
platelet | 3 studies | 27% ± 9% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 7064.61 | 180 / 180 | 98% | 22.33 | 421 / 430 |
breast | 99% | 5147.81 | 456 / 459 | 96% | 19.63 | 1076 / 1118 |
prostate | 97% | 8288.81 | 237 / 245 | 98% | 27.31 | 493 / 502 |
lung | 99% | 5182.61 | 570 / 578 | 96% | 18.38 | 1104 / 1155 |
bladder | 100% | 14680.00 | 21 / 21 | 93% | 18.72 | 470 / 504 |
uterus | 99% | 21109.26 | 169 / 170 | 91% | 28.36 | 418 / 459 |
intestine | 90% | 14276.71 | 867 / 966 | 98% | 19.97 | 519 / 527 |
esophagus | 84% | 12909.64 | 1217 / 1445 | 99% | 23.41 | 181 / 183 |
thymus | 87% | 2609.10 | 570 / 653 | 95% | 22.82 | 573 / 605 |
stomach | 66% | 5950.10 | 238 / 359 | 98% | 26.84 | 280 / 286 |
skin | 69% | 2762.63 | 1249 / 1809 | 95% | 28.53 | 447 / 472 |
kidney | 61% | 1826.44 | 54 / 89 | 76% | 15.20 | 686 / 901 |
adrenal gland | 33% | 757.50 | 86 / 258 | 85% | 13.23 | 195 / 230 |
blood vessel | 100% | 17101.55 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.79 | 1 / 1 |
pancreas | 1% | 19.73 | 2 / 328 | 98% | 32.71 | 175 / 178 |
adipose | 99% | 5408.03 | 1191 / 1204 | 0% | 0 | 0 / 0 |
brain | 0% | 6.36 | 6 / 2642 | 90% | 14.45 | 636 / 705 |
eye | 0% | 0 | 0 / 0 | 86% | 10.42 | 69 / 80 |
spleen | 83% | 2835.59 | 199 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 10.58 | 37 / 45 |
lymph node | 0% | 0 | 0 / 0 | 72% | 6.29 | 21 / 29 |
heart | 60% | 1973.19 | 518 / 861 | 0% | 0 | 0 / 0 |
liver | 2% | 53.87 | 5 / 226 | 46% | 4.33 | 187 / 406 |
muscle | 3% | 81.33 | 25 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 2.63 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030511 | Biological process | positive regulation of transforming growth factor beta receptor signaling pathway |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0030855 | Biological process | epithelial cell differentiation |
GO_0045599 | Biological process | negative regulation of fat cell differentiation |
GO_0007155 | Biological process | cell adhesion |
GO_0016331 | Biological process | morphogenesis of embryonic epithelium |
GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
GO_0045165 | Biological process | cell fate commitment |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0045444 | Biological process | fat cell differentiation |
GO_0005856 | Cellular component | cytoskeleton |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0005925 | Cellular component | focal adhesion |
GO_0016363 | Cellular component | nuclear matrix |
GO_0005829 | Cellular component | cytosol |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0048495 | Molecular function | Roundabout binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0050681 | Molecular function | nuclear androgen receptor binding |
GO_0070411 | Molecular function | I-SMAD binding |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TGFB1I1 |
Protein name | Transforming growth factor beta 1 induced transcript 1 Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) |
Synonyms | ARA55 |
Description | FUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. . |
Accessions | ENST00000562566.5 O43294 ENST00000361773.7 [O43294-2] H3BQC4 ENST00000394863.8 [O43294-1] ENST00000567066.6 ENST00000565360.5 I3L209 ENST00000567607.5 [O43294-2] H3BS04 H3BRP2 ENST00000563712.6 ENST00000564804.1 H3BN49 ENST00000394858.6 [O43294-2] ENST00000565454.5 H3BSN4 |