TGFB1I1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030855Biological processepithelial cell differentiation
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0007155Biological processcell adhesion
GO_0016331Biological processmorphogenesis of embryonic epithelium
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0045165Biological processcell fate commitment
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0016055Biological processWnt signaling pathway
GO_0045444Biological processfat cell differentiation
GO_0005856Cellular componentcytoskeleton
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005925Cellular componentfocal adhesion
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0048495Molecular functionRoundabout binding
GO_0046872Molecular functionmetal ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0070411Molecular functionI-SMAD binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTGFB1I1
Protein nameTransforming growth factor beta 1 induced transcript 1
Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)
SynonymsARA55
DescriptionFUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. .

AccessionsENST00000562566.5
O43294
ENST00000361773.7 [O43294-2]
H3BQC4
ENST00000394863.8 [O43294-1]
ENST00000567066.6
ENST00000565360.5
I3L209
ENST00000567607.5 [O43294-2]
H3BS04
H3BRP2
ENST00000563712.6
ENST00000564804.1
H3BN49
ENST00000394858.6 [O43294-2]
ENST00000565454.5
H3BSN4