NPM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902751Biological processpositive regulation of cell cycle G2/M phase transition
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006281Biological processDNA repair
GO_0032071Biological processregulation of endodeoxyribonuclease activity
GO_0044387Biological processnegative regulation of protein kinase activity by regulation of protein phosphorylation
GO_0034644Biological processcellular response to UV
GO_0007165Biological processsignal transduction
GO_0006886Biological processintracellular protein transport
GO_0060699Biological processregulation of endoribonuclease activity
GO_0046599Biological processregulation of centriole replication
GO_0006338Biological processchromatin remodeling
GO_0006334Biological processnucleosome assembly
GO_0007098Biological processcentrosome cycle
GO_0042274Biological processribosomal small subunit biogenesis
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042273Biological processribosomal large subunit biogenesis
GO_0010824Biological processregulation of centrosome duplication
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0000056Biological processribosomal small subunit export from nucleus
GO_0045727Biological processpositive regulation of translation
GO_0006913Biological processnucleocytoplasmic transport
GO_0010826Biological processnegative regulation of centrosome duplication
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0090398Biological processcellular senescence
GO_0008104Biological processprotein localization
GO_1902629Biological processregulation of mRNA stability involved in cellular response to UV
GO_0060735Biological processregulation of eIF2 alpha phosphorylation by dsRNA
GO_0042255Biological processribosome assembly
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000055Biological processribosomal large subunit export from nucleus
GO_0005730Cellular componentnucleolus
GO_0001652Cellular componentgranular component
GO_0032993Cellular componentprotein-DNA complex
GO_0016020Cellular componentmembrane
GO_0031616Cellular componentspindle pole centrosome
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0051059Molecular functionNF-kappaB binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019843Molecular functionrRNA binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0030957Molecular functionTat protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0043024Molecular functionribosomal small subunit binding
GO_0051082Molecular functionunfolded protein binding
GO_0003723Molecular functionRNA binding
GO_0043023Molecular functionribosomal large subunit binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNPM1
Protein nameNucleophosmin
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Mutant NPM1 protein
SynonymsNPM
hCG_1979311
DescriptionFUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade . In complex with MYC enhances the transcription of MYC target genes . May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). .

AccessionsENST00000393820.2 [P06748-3]
ENST00000517671.5 [P06748-1]
A0A7I2V2X9
ENST00000521672.6
B1PHD4
A4ZU86
ENST00000678774.1
A0A7I2V3G5
ENST00000351986.10 [P06748-2]
E5RI98
ENST00000679190.1
ENST00000677357.1
P06748
A0A7I2V5S2
ENST00000678267.1
ENST00000677907.1
ENST00000523622.1
A0A7I2V4G8
E5RGW4
A0A0S2Z491
ENST00000676589.1
ENST00000296930.10 [P06748-1]
A0A0S2Z4G7
ENST00000677297.1
ENST00000676613.1
A0A7I2YQC0
ENST00000678280.1 [P06748-3]
ENST00000677325.1
A0A7I2V3U2
A0A7I2V579
A0A7I2V433
Q9BTI9
A0A7I2V5J8
ENST00000679233.1