FLNC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLNC at tissue level.

III. Associated gene sets

GO_0045214Biological processsarcomere organization
GO_0042383Cellular componentsarcolemma
GO_0005856Cellular componentcytoskeleton
GO_0016528Cellular componentsarcoplasm
GO_0005829Cellular componentcytosol
GO_0030018Cellular componentZ disc
GO_0005886Cellular componentplasma membrane
GO_0043034Cellular componentcostamere
GO_0005737Cellular componentcytoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005925Cellular componentfocal adhesion
GO_0030506Molecular functionankyrin binding
GO_0051015Molecular functionactin filament binding
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFLNC
Protein nameFilamin C
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
SynonymsABPL
FLN2
DescriptionFUNCTION: Muscle-specific filamin, which plays a central role in sarcomere assembly and organization . Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). .

AccessionsQ14315
ENST00000346177.6 [Q14315-2]
ENST00000325888.13 [Q14315-1]
B5AGT3