BSG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0001525Biological processangiogenesis
GO_0072659Biological processprotein localization to plasma membrane
GO_0043434Biological processresponse to peptide hormone
GO_0046697Biological processdecidualization
GO_0030593Biological processneutrophil chemotaxis
GO_0046718Biological processsymbiont entry into host cell
GO_0051591Biological processresponse to cAMP
GO_0046689Biological processresponse to mercury ion
GO_0007566Biological processembryo implantation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0002080Cellular componentacrosomal membrane
GO_0042383Cellular componentsarcolemma
GO_0070062Cellular componentextracellular exosome
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005768Cellular componentendosome
GO_0042470Cellular componentmelanosome
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005537Molecular functionD-mannose binding
GO_0045296Molecular functioncadherin binding
GO_0001618Molecular functionvirus receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBSG
Protein nameBasigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
Basigin
Basigin (Ok blood group)
SynonymsUNQ6505/PRO21383
hCG_20562
hEMMPRIN
DescriptionFUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors . In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors . May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes . .; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. .; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells . Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane . Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling . Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells . Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) . .; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 . Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte . This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion . .; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. .; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. .; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. .; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. .; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. .

AccessionsENST00000545507.6 [P35613-3]
ENST00000618006.4
R4GN83
P35613
A0A087X215
A0A2R8YDZ0
ENST00000614867.2
A0A087WUV8
ENST00000576984.3 [P35613-3]
ENST00000680552.1
ENST00000346916.9 [P35613-3]
ENST00000680326.1
ENST00000576984
ENST00000618112.4
ENST00000353555.9 [P35613-2]
Q54A51
ENST00000613627.5
ENST00000573784.6 [P35613-3]
ENST00000333511.9 [P35613-1]
ENST00000680065.1 [P35613-3]
A0A7P0TB04
R4GMX5
ENST00000573216.5
A0A7P0TA85
ENST00000573784
A0A087X2B5
ENST00000679472.1
A0A7P0T8A7
I3L192