Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 42% ± 16% | |
| fibroblast | 15 studies | 22% ± 9% | |
| basal cell | 10 studies | 27% ± 11% | |
| myofibroblast cell | 9 studies | 34% ± 14% | |
| smooth muscle cell | 9 studies | 26% ± 9% | |
| connective tissue cell | 6 studies | 35% ± 20% | |
| pericyte | 4 studies | 23% ± 7% | |
| epithelial cell | 3 studies | 31% ± 12% |
Insufficient scRNA-seq data for expression of TNC at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 72% | 14234.02 | 1304 / 1809 | 85% | 249.39 | 400 / 472 |
| lung | 80% | 16869.38 | 461 / 578 | 76% | 160.55 | 880 / 1155 |
| esophagus | 75% | 11678.38 | 1083 / 1445 | 74% | 298.43 | 135 / 183 |
| uterus | 82% | 21869.15 | 140 / 170 | 66% | 114.49 | 303 / 459 |
| breast | 66% | 7175.96 | 303 / 459 | 78% | 116.89 | 871 / 1118 |
| prostate | 81% | 11112.02 | 199 / 245 | 62% | 33.53 | 311 / 502 |
| intestine | 86% | 38843.98 | 831 / 966 | 46% | 40.24 | 244 / 527 |
| stomach | 60% | 17715.33 | 216 / 359 | 54% | 62.61 | 154 / 286 |
| bladder | 62% | 7990.48 | 13 / 21 | 45% | 54.16 | 225 / 504 |
| kidney | 46% | 7223.98 | 41 / 89 | 53% | 61.89 | 474 / 901 |
| blood vessel | 91% | 67251.52 | 1221 / 1335 | 0% | 0 | 0 / 0 |
| brain | 4% | 262.90 | 110 / 2642 | 85% | 139.28 | 600 / 705 |
| thymus | 34% | 3789.25 | 223 / 653 | 47% | 40.42 | 287 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 143.69 | 32 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 51.61 | 20 / 29 |
| spleen | 62% | 5136.66 | 150 / 241 | 0% | 0 | 0 / 0 |
| adipose | 53% | 9208.29 | 643 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 64.94 | 2 / 328 | 49% | 43.21 | 87 / 178 |
| heart | 35% | 5066.48 | 303 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 8% | 617.24 | 20 / 258 | 21% | 16.72 | 48 / 230 |
| ovary | 8% | 1331.32 | 15 / 180 | 19% | 11.10 | 82 / 430 |
| liver | 4% | 251.82 | 8 / 226 | 6% | 8.79 | 26 / 406 |
| muscle | 6% | 549.34 | 51 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.38 | 1 / 80 |
| peripheral blood | 0% | 4.95 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0071799 | Biological process | cellular response to prostaglandin D stimulus |
| GO_0002009 | Biological process | morphogenesis of an epithelium |
| GO_0001558 | Biological process | regulation of cell growth |
| GO_0071305 | Biological process | cellular response to vitamin D |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0007155 | Biological process | cell adhesion |
| GO_0014012 | Biological process | peripheral nervous system axon regeneration |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0045471 | Biological process | response to ethanol |
| GO_0007528 | Biological process | neuromuscular junction development |
| GO_0071774 | Biological process | response to fibroblast growth factor |
| GO_0060447 | Biological process | bud outgrowth involved in lung branching |
| GO_0060740 | Biological process | prostate gland epithelium morphogenesis |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0030155 | Biological process | regulation of cell adhesion |
| GO_0060739 | Biological process | mesenchymal-epithelial cell signaling involved in prostate gland development |
| GO_0009611 | Biological process | response to wounding |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005614 | Cellular component | interstitial matrix |
| GO_0005576 | Cellular component | extracellular region |
| GO_0098966 | Cellular component | perisynaptic extracellular matrix |
| GO_0016020 | Cellular component | membrane |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005604 | Cellular component | basement membrane |
| GO_0090733 | Cellular component | tenascin complex |
| GO_0005201 | Molecular function | extracellular matrix structural constituent |
| GO_0045545 | Molecular function | syndecan binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TNC |
| Protein name | TNC protein Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) Tenascin-C additional domain 1 TNC variant protein Tenascin C |
| Synonyms | HXB protein variant |
| Description | FUNCTION: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells . . |
| Accessions | J3QSU6 ENST00000705190.1 ENST00000705191.1 A0A994J7R0 ENST00000341037.8 A0A994J4S6 E9PC84 Q4LE33 ENST00000473855.1 ENST00000350763.9 [P24821-1] A7MBN2 P24821 ENST00000542877.6 ENST00000705192.1 A0A994J5G0 H0YGZ3 F5H5D6 ENST00000481475.1 A9YUB8 A0A0U1RR80 F5H7V9 ENST00000423613.6 ENST00000537320.6 [P24821-6] ENST00000544972.1 A0A994J7C1 ENST00000635336.1 ENST00000476680.2 A0A994J510 A0A994J7R4 ENST00000534839.1 |
