SRP68 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006614Biological processSRP-dependent cotranslational protein targeting to membrane
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0005730Cellular componentnucleolus
GO_0005786Cellular componentsignal recognition particle, endoplasmic reticulum targeting
GO_0048500Cellular componentsignal recognition particle
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005840Cellular componentribosome
GO_0005925Cellular componentfocal adhesion
GO_0043022Molecular functionribosome binding
GO_0005047Molecular functionsignal recognition particle binding
GO_0030942Molecular functionendoplasmic reticulum signal peptide binding
GO_0019904Molecular functionprotein domain specific binding
GO_0008312Molecular function7S RNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSRP68
Protein nameSignal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)
Signal recognition particle 68
Synonyms
DescriptionFUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) . The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER . The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER . Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently . The SRP complex possibly participates in the elongation arrest function (By similarity). .

AccessionsK7EN53
Q9UHB9
ENST00000629930.1
ENST00000602720.5 [Q9UHB9-3]
ENST00000592704.5
K7EQC2
ENST00000591272.1
ENST00000307877.7 [Q9UHB9-1]
ENST00000539137.5 [Q9UHB9-4]