TNS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019725Biological processcellular homeostasis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0035264Biological processmulticellular organism growth
GO_0001822Biological processkidney development
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0014850Biological processresponse to muscle activity
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0048871Biological processmulticellular organismal-level homeostasis
GO_0032963Biological processcollagen metabolic process
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding
GO_0046872Molecular functionmetal ion binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameTNS2
Protein nameTensin like C1 domain containing phosphatase (Tensin 2)
Tensin 2
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
SynonymsTENC1
KIAA1075
DescriptionFUNCTION: Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin . Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain . In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy . Negatively regulates PI3K-AKT pathway activation . Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex . Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria . Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 . Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix . .

AccessionsQ63HR2
F8VV64
ENST00000314276.7 [Q63HR2-4]
ENST00000379902.7 [Q63HR2-5]
ENST00000546602.5 [Q63HR2-2]
ENST00000546772.1
A7E2A6
R4GMX1
ENST00000552570.5 [Q63HR2-6]
ENST00000602335.1
ENST00000314250.11 [Q63HR2-1]
ENST00000549700.5
H0YID7