CNN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	30 studies	44% ± 21%	Explore
B cell	29 studies	38% ± 16%	Explore
CD4-positive, alpha-beta T cell	29 studies	44% ± 19%	Explore
conventional dendritic cell	26 studies	47% ± 20%	Explore
regulatory T cell	25 studies	45% ± 19%	Explore
T cell	24 studies	40% ± 19%	Explore
fibroblast	22 studies	31% ± 13%	Explore
natural killer cell	20 studies	33% ± 12%	Explore
memory B cell	20 studies	46% ± 15%	Explore
classical monocyte	20 studies	31% ± 14%	Explore
naive B cell	19 studies	42% ± 13%	Explore
non-classical monocyte	19 studies	35% ± 15%	Explore
mature NK T cell	17 studies	35% ± 20%	Explore
gamma-delta T cell	16 studies	40% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	44% ± 18%	Explore
basal cell	16 studies	31% ± 12%	Explore
monocyte	15 studies	29% ± 8%	Explore
dendritic cell	14 studies	53% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	38% ± 15%	Explore
mucosal invariant T cell	14 studies	53% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	52% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 8%	Explore
plasmacytoid dendritic cell	13 studies	32% ± 10%	Explore
pericyte	13 studies	25% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	46% ± 22%	Explore
epithelial cell	12 studies	27% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	44% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	49% ± 22%	Explore
macrophage	11 studies	22% ± 7%	Explore
connective tissue cell	11 studies	38% ± 21%	Explore
smooth muscle cell	10 studies	34% ± 16%	Explore
plasmablast	9 studies	39% ± 21%	Explore
type I pneumocyte	8 studies	33% ± 16%	Explore
myofibroblast cell	8 studies	45% ± 21%	Explore
neutrophil	7 studies	26% ± 8%	Explore
hematopoietic stem cell	7 studies	34% ± 12%	Explore
T follicular helper cell	7 studies	39% ± 15%	Explore
hematopoietic precursor cell	6 studies	39% ± 9%	Explore
plasma cell	6 studies	36% ± 16%	Explore
secretory cell	6 studies	24% ± 10%	Explore
platelet	6 studies	27% ± 10%	Explore
myeloid cell	6 studies	33% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	58% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	54% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	49% ± 20%	Explore
exhausted T cell	5 studies	66% ± 15%	Explore
endothelial cell	5 studies	22% ± 10%	Explore
immature B cell	5 studies	57% ± 22%	Explore
type II pneumocyte	5 studies	29% ± 16%	Explore
double negative thymocyte	5 studies	54% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	66% ± 25%	Explore
club cell	4 studies	24% ± 8%	Explore
megakaryocyte	4 studies	34% ± 12%	Explore
T-helper 17 cell	4 studies	43% ± 26%	Explore
ciliated cell	4 studies	29% ± 7%	Explore
abnormal cell	4 studies	31% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	44% ± 15%	Explore
CD4-positive helper T cell	3 studies	32% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	56% ± 20%	Explore
squamous epithelial cell	3 studies	44% ± 21%	Explore
mononuclear phagocyte	3 studies	29% ± 10%	Explore
progenitor cell	3 studies	41% ± 18%	Explore
leukocyte	3 studies	29% ± 6%	Explore
mesothelial cell	3 studies	30% ± 12%	Explore
common myeloid progenitor	3 studies	40% ± 21%	Explore
precursor B cell	3 studies	44% ± 15%	Explore
germinal center B cell	3 studies	58% ± 15%	Explore
intermediate monocyte	3 studies	45% ± 22%	Explore
innate lymphoid cell	3 studies	41% ± 18%	Explore
T-helper 1 cell	3 studies	49% ± 23%	Explore
mast cell	3 studies	32% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	56% ± 21%	Explore
double-positive, alpha-beta thymocyte	3 studies	56% ± 21%	Explore
erythrocyte	3 studies	33% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	38% ± 11%	Explore
lung	10 studies	29% ± 10%	Explore
intestine	4 studies	27% ± 6%	Explore
bone marrow	4 studies	34% ± 16%	Explore
liver	4 studies	20% ± 4%	Explore
kidney	3 studies	35% ± 7%	Explore
lymph node	3 studies	40% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	12936.72	578 / 578	100%	183.26	1153 / 1155
intestine	100%	5196.47	963 / 966	99%	160.57	522 / 527
stomach	100%	5053.34	359 / 359	99%	138.51	282 / 286
esophagus	100%	6820.67	1444 / 1445	98%	126.16	179 / 183
uterus	100%	8766.09	170 / 170	98%	165.48	448 / 459
thymus	100%	7186.34	651 / 653	98%	161.48	590 / 605
breast	100%	7364.78	459 / 459	97%	123.52	1080 / 1118
bladder	100%	6639.48	21 / 21	95%	160.14	480 / 504
pancreas	96%	3314.17	314 / 328	97%	166.92	172 / 178
prostate	100%	7423.49	245 / 245	91%	63.04	455 / 502
skin	100%	10865.74	1808 / 1809	90%	93.77	424 / 472
ovary	100%	13409.39	180 / 180	88%	93.02	379 / 430
kidney	100%	5037.81	89 / 89	80%	50.28	725 / 901
liver	62%	1556.60	139 / 226	67%	40.53	274 / 406
lymph node	0%	0	0 / 0	100%	235.17	29 / 29
spleen	100%	12811.80	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	123.59	1 / 1
blood vessel	100%	8708.69	1334 / 1335	0%	0	0 / 0
adipose	100%	6318.27	1203 / 1204	0%	0	0 / 0
peripheral blood	100%	26402.84	927 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	197.34	44 / 45
heart	89%	3090.13	766 / 861	0%	0	0 / 0
adrenal gland	63%	1454.61	162 / 258	18%	10.08	41 / 230
eye	0%	0	0 / 0	75%	36.26	60 / 80
brain	1%	15.61	22 / 2642	28%	15.11	197 / 705
muscle	2%	43.77	17 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030097	Biological process	hemopoiesis
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0032970	Biological process	regulation of actin filament-based process
GO_0010628	Biological process	positive regulation of gene expression
GO_0007010	Biological process	cytoskeleton organization
GO_0051649	Biological process	establishment of localization in cell
GO_0031032	Biological process	actomyosin structure organization
GO_0042060	Biological process	wound healing
GO_0050765	Biological process	negative regulation of phagocytosis
GO_0032944	Biological process	regulation of mononuclear cell proliferation
GO_1905517	Biological process	macrophage migration
GO_0007015	Biological process	actin filament organization
GO_1905522	Biological process	negative regulation of macrophage migration
GO_0006909	Biological process	phagocytosis
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0035580	Cellular component	specific granule lumen
GO_0016020	Cellular component	membrane
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_1904724	Cellular component	tertiary granule lumen
GO_0045296	Molecular function	cadherin binding
GO_0051015	Molecular function	actin filament binding
GO_0005516	Molecular function	calmodulin binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	CNN2
Protein name	Calponin 2 Calponin Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)
Synonyms
Description	FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. . FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. .
Accessions	U3KPS3 A0A087X1X5 H3BQH0 A0A087X271 ENST00000348419.7 [Q99439-2] ENST00000263097.9 [Q99439-1] ENST00000566695.5 Q99439 B2RWM5 ENST00000565096.6 Q6FHE4 H3BVI6 K7ES69 ENST00000568865.3 ENST00000562075.6 B4DDF4 ENST00000569352.6 ENST00000562958.6 ENST00000562015.5 A0A087WV51 B4DUT8 ENST00000607102.1 ENST00000606983.5 Q6FHC3

CNN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review