Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 23 studies | 35% ± 21% | |
fibroblast | 15 studies | 33% ± 14% | |
astrocyte | 14 studies | 34% ± 18% | |
oligodendrocyte precursor cell | 14 studies | 48% ± 19% | |
pericyte | 13 studies | 29% ± 13% | |
microglial cell | 12 studies | 47% ± 18% | |
endothelial cell | 11 studies | 31% ± 11% | |
myeloid cell | 10 studies | 41% ± 22% | |
type I pneumocyte | 9 studies | 41% ± 19% | |
adipocyte | 9 studies | 44% ± 9% | |
dendritic cell | 7 studies | 21% ± 4% | |
ciliated cell | 6 studies | 29% ± 13% | |
epithelial cell | 6 studies | 31% ± 6% | |
monocyte | 5 studies | 39% ± 14% | |
smooth muscle cell | 5 studies | 23% ± 6% | |
classical monocyte | 4 studies | 16% ± 2% | |
retinal pigment epithelial cell | 4 studies | 47% ± 20% | |
cardiac muscle cell | 4 studies | 17% ± 1% | |
alveolar macrophage | 4 studies | 56% ± 26% | |
club cell | 4 studies | 28% ± 12% | |
neuron | 4 studies | 51% ± 21% | |
cholangiocyte | 3 studies | 43% ± 17% | |
hepatic stellate cell | 3 studies | 44% ± 19% | |
GABAergic neuron | 3 studies | 23% ± 7% | |
glial cell | 3 studies | 29% ± 11% | |
Mueller cell | 3 studies | 23% ± 3% | |
hepatocyte | 3 studies | 71% ± 21% | |
connective tissue cell | 3 studies | 34% ± 12% | |
B cell | 3 studies | 26% ± 3% | |
basal cell | 3 studies | 51% ± 17% | |
chondrocyte | 3 studies | 35% ± 7% | |
type II pneumocyte | 3 studies | 22% ± 4% | |
transit amplifying cell | 3 studies | 39% ± 33% | |
mesothelial cell | 3 studies | 49% ± 7% | |
podocyte | 3 studies | 55% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 6707.38 | 358 / 359 | 100% | 46.54 | 285 / 286 |
brain | 100% | 8410.34 | 2629 / 2642 | 100% | 59.95 | 702 / 705 |
kidney | 100% | 12932.67 | 89 / 89 | 99% | 67.71 | 888 / 901 |
intestine | 99% | 6018.90 | 959 / 966 | 99% | 41.06 | 521 / 527 |
ovary | 100% | 9814.35 | 180 / 180 | 98% | 51.90 | 421 / 430 |
pancreas | 100% | 9225.13 | 328 / 328 | 98% | 40.90 | 174 / 178 |
breast | 100% | 6813.00 | 458 / 459 | 97% | 43.57 | 1085 / 1118 |
skin | 97% | 8385.78 | 1762 / 1809 | 99% | 90.81 | 469 / 472 |
liver | 100% | 7623.85 | 226 / 226 | 95% | 33.72 | 384 / 406 |
lung | 100% | 12803.05 | 578 / 578 | 94% | 37.79 | 1084 / 1155 |
thymus | 100% | 9454.00 | 653 / 653 | 90% | 25.21 | 542 / 605 |
bladder | 100% | 4040.95 | 21 / 21 | 85% | 28.05 | 426 / 504 |
prostate | 98% | 5229.19 | 240 / 245 | 80% | 17.40 | 402 / 502 |
uterus | 99% | 8185.34 | 168 / 170 | 76% | 21.06 | 349 / 459 |
esophagus | 78% | 3369.63 | 1127 / 1445 | 89% | 36.65 | 163 / 183 |
adrenal gland | 100% | 10506.22 | 258 / 258 | 60% | 14.96 | 139 / 230 |
adipose | 100% | 8627.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 12496.25 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 27.78 | 1 / 1 |
blood vessel | 100% | 11735.22 | 1329 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 27.43 | 76 / 80 |
muscle | 94% | 3604.38 | 753 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 44.83 | 27 / 29 |
heart | 93% | 4259.52 | 799 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 22.55 | 36 / 45 |
peripheral blood | 8% | 159.30 | 71 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042995 | Cellular component | cell projection |
GO_0002102 | Cellular component | podosome |
GO_0005829 | Cellular component | cytosol |
GO_0005925 | Cellular component | focal adhesion |
GO_0004721 | Molecular function | phosphoprotein phosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TNS3 |
Protein name | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) Tensin 3 |
Synonyms | TENS1 TEM6 hCG_2006842 TPP |
Description | FUNCTION: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex . EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 . Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 . Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation . Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA . Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration . Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 . . |
Accessions | ENST00000705472.1 ENST00000705473.1 ENST00000705474.1 ENST00000434451.1 H7BZ64 C9JUW5 E9PCX8 A0A994J7T8 ENST00000413551.1 A0A994J7F3 ENST00000450444.6 A0A994J4W0 ENST00000705350.1 ENST00000442536.6 [Q68CZ2-4] C9JHU5 Q68CZ2 ENST00000415929.5 ENST00000428457.1 C9JWN9 ENST00000311160.14 [Q68CZ2-1] ENST00000457718.6 A0A994J537 C9JTD0 |