TNS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042995Cellular componentcell projection
GO_0002102Cellular componentpodosome
GO_0005829Cellular componentcytosol
GO_0005925Cellular componentfocal adhesion
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNS3
Protein nameTensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)
Tensin 3
SynonymsTENS1
TEM6
hCG_2006842
TPP
DescriptionFUNCTION: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex . EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 . Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 . Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation . Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA . Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration . Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 . .

AccessionsENST00000705472.1
ENST00000705473.1
ENST00000705474.1
ENST00000434451.1
H7BZ64
C9JUW5
E9PCX8
A0A994J7T8
ENST00000413551.1
A0A994J7F3
ENST00000450444.6
A0A994J4W0
ENST00000705350.1
ENST00000442536.6 [Q68CZ2-4]
C9JHU5
Q68CZ2
ENST00000415929.5
ENST00000428457.1
C9JWN9
ENST00000311160.14 [Q68CZ2-1]
ENST00000457718.6
A0A994J537
C9JTD0