PARVB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0030036Biological processactin cytoskeleton organization
GO_0030031Biological processcell projection assembly
GO_0071963Biological processestablishment or maintenance of cell polarity regulating cell shape
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0030032Biological processlamellipodium assembly
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0030018Cellular componentZ disc
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePARVB
Protein nameBeta-parvin (Affixin)
Parvin beta
SynonymsCGI-56
DescriptionFUNCTION: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. .

AccessionsB0QYP8
ENST00000404989.1 [Q9HBI1-3]
ENST00000338758.12 [Q9HBI1-1]
ENST00000619710.4
A0A087WZB5
ENST00000444029.5
Q9HBI1
ENST00000406477.7 [Q9HBI1-2]