PAK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0001558Biological processregulation of cell growth
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007165Biological processsignal transduction
GO_0007010Biological processcytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0060996Biological processdendritic spine development
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0098609Biological processcell-cell adhesion
GO_0071407Biological processcellular response to organic cyclic compound
GO_0016477Biological processcell migration
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAK4
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
cDNA FLJ61413, highly similar to Serine/threonine-protein kinase PAK 4 (p21(CDKN1A)-activated kinase 4, isoform CRA_e)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
P21 (RAC1) activated kinase 4
SynonymsKIAA1142
hCG_20282
DescriptionFUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. .

AccessionsENST00000593690.5 [O96013-1]
ENST00000599386.5 [O96013-3]
M0R3G6
O96013
ENST00000599657.5
ENST00000360442.8 [O96013-1]
M0R0L9
M0R2X4
ENST00000593480.5
ENST00000599470.5 [O96013-3]
B4DUG0
M0R1R1
ENST00000321944.8 [O96013-4]
ENST00000358301.7 [O96013-1]
ENST00000597715.1
ENST00000602004.1