TWF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030837Biological processnegative regulation of actin filament polymerization
GO_0051016Biological processbarbed-end actin filament capping
GO_0043538Biological processregulation of actin phosphorylation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0030042Biological processactin filament depolymerization
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0042989Biological processsequestering of actin monomers
GO_0010591Biological processregulation of lamellipodium assembly
GO_0032587Cellular componentruffle membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030016Cellular componentmyofibril
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0030175Cellular componentfilopodium
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0003785Molecular functionactin monomer binding
GO_0045296Molecular functioncadherin binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameTWF1
Protein nameTwinfilin-1
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Twinfilin actin binding protein 1
SynonymsPTK9
DescriptionFUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). .

FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. .

FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. .

AccessionsENST00000395510.7 [Q12792-2]
Q12792
F8W645
ENST00000552521.5 [Q12792-4]
ENST00000550371.1
ENST00000546506.5
F8VRG3
F8W1Q9
ENST00000548403.1
ENST00000546662.5
ENST00000547459.5
F8W1D0
F8VS81
ENST00000548315.5 [Q12792-3]