SPRY4 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	10 studies	22% ± 3%	Explore
oligodendrocyte precursor cell	9 studies	30% ± 13%	Explore
pericyte	8 studies	29% ± 11%	Explore
glomerular endothelial cell	3 studies	22% ± 5%	Explore
GABAergic neuron	3 studies	19% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPRY4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	99%	2164.09	957 / 966	98%	30.14	517 / 527
adrenal gland	100%	4477.82	258 / 258	96%	89.81	220 / 230
stomach	93%	1741.63	335 / 359	98%	26.47	279 / 286
breast	98%	3611.26	452 / 459	92%	20.46	1032 / 1118
lung	100%	6801.92	578 / 578	90%	24.02	1035 / 1155
thymus	100%	5104.28	653 / 653	88%	27.69	532 / 605
kidney	100%	3041.24	89 / 89	82%	45.33	735 / 901
bladder	95%	1531.43	20 / 21	85%	19.25	428 / 504
esophagus	78%	1386.39	1129 / 1445	90%	25.62	165 / 183
prostate	97%	2406.38	237 / 245	71%	15.28	354 / 502
skin	68%	1621.79	1237 / 1809	99%	170.59	465 / 472
brain	89%	1493.30	2354 / 2642	61%	28.24	428 / 705
uterus	94%	1564.16	159 / 170	55%	16.03	254 / 459
liver	92%	1638.32	207 / 226	55%	9.46	223 / 406
pancreas	42%	428.93	138 / 328	97%	28.36	173 / 178
ovary	31%	399.82	55 / 180	81%	20.97	350 / 430
adipose	100%	5735.53	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	10.96	1 / 1
blood vessel	100%	6482.97	1332 / 1335	0%	0	0 / 0
heart	99%	2985.29	855 / 861	0%	0	0 / 0
spleen	97%	2298.99	234 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	94%	23.57	75 / 80
tonsil	0%	0	0 / 0	58%	7.15	26 / 45
muscle	44%	490.71	353 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	17%	2.20	5 / 29
peripheral blood	6%	70.02	60 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_1900025	Biological process	negative regulation of substrate adhesion-dependent cell spreading
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0040037	Biological process	negative regulation of fibroblast growth factor receptor signaling pathway
GO_0046580	Biological process	negative regulation of Ras protein signal transduction
GO_0048513	Biological process	animal organ development
GO_0032587	Cellular component	ruffle membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0005515	Molecular function	protein binding

Gene name	SPRY4
Protein name	Sprouty RTK signaling antagonist 4 Protein sprouty homolog 4 (Spry-4)
Synonyms
Description	FUNCTION: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras . Probably impairs the formation of GTP-Ras . Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 . Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin . .
Accessions	D6RB56 A0A0C4DFS6 ENST00000511815.1 ENST00000434127.3 [Q9C004-1] Q9C004 ENST00000344120.4

SPRY4 report