Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 13 studies | 35% ± 14% | |
| astrocyte | 13 studies | 32% ± 13% | |
| endothelial cell | 11 studies | 25% ± 8% | |
| ciliated cell | 7 studies | 26% ± 11% | |
| vein endothelial cell | 7 studies | 24% ± 10% | |
| endothelial cell of lymphatic vessel | 7 studies | 24% ± 7% | |
| epithelial cell | 6 studies | 26% ± 9% | |
| endothelial cell of artery | 4 studies | 23% ± 5% | |
| mucus secreting cell | 4 studies | 20% ± 4% | |
| hillock cell | 3 studies | 27% ± 8% | |
| placental villous trophoblast | 3 studies | 32% ± 13% | |
| ependymal cell | 3 studies | 37% ± 20% | |
| goblet cell | 3 studies | 19% ± 2% | |
| Schwann cell | 3 studies | 51% ± 20% | |
| brush cell | 3 studies | 26% ± 5% | |
| myoepithelial cell | 3 studies | 30% ± 4% |
Insufficient scRNA-seq data for expression of ITGB4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 9282.88 | 1441 / 1445 | 99% | 484.98 | 181 / 183 |
| intestine | 99% | 11077.53 | 961 / 966 | 98% | 238.33 | 514 / 527 |
| bladder | 100% | 9030.81 | 21 / 21 | 93% | 260.24 | 471 / 504 |
| stomach | 97% | 8205.38 | 350 / 359 | 94% | 240.73 | 268 / 286 |
| uterus | 91% | 4941.21 | 154 / 170 | 80% | 240.36 | 367 / 459 |
| breast | 92% | 12150.46 | 422 / 459 | 72% | 79.14 | 810 / 1118 |
| lung | 57% | 2236.93 | 329 / 578 | 86% | 213.82 | 995 / 1155 |
| prostate | 99% | 12797.91 | 243 / 245 | 43% | 26.93 | 216 / 502 |
| thymus | 62% | 2238.62 | 402 / 653 | 55% | 49.72 | 334 / 605 |
| pancreas | 23% | 739.82 | 74 / 328 | 92% | 283.16 | 163 / 178 |
| brain | 55% | 3095.24 | 1455 / 2642 | 55% | 56.27 | 390 / 705 |
| spleen | 100% | 9117.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 78.19 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 321.86 | 44 / 45 |
| ovary | 12% | 479.05 | 21 / 180 | 85% | 139.53 | 364 / 430 |
| skin | 72% | 20643.71 | 1306 / 1809 | 20% | 22.89 | 93 / 472 |
| adipose | 84% | 5358.36 | 1009 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 29% | 1234.81 | 26 / 89 | 37% | 28.90 | 334 / 901 |
| blood vessel | 37% | 1928.45 | 497 / 1335 | 0% | 0 | 0 / 0 |
| heart | 24% | 808.21 | 206 / 861 | 0% | 0 | 0 / 0 |
| liver | 1% | 25.10 | 2 / 226 | 13% | 20.98 | 51 / 406 |
| eye | 0% | 0 | 0 / 0 | 9% | 5.34 | 7 / 80 |
| adrenal gland | 2% | 195.90 | 5 / 258 | 1% | 0.86 | 2 / 230 |
| muscle | 2% | 69.03 | 18 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 10.61 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0048870 | Biological process | cell motility |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0035878 | Biological process | nail development |
| GO_0007155 | Biological process | cell adhesion |
| GO_0048333 | Biological process | mesodermal cell differentiation |
| GO_0061450 | Biological process | trophoblast cell migration |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0032290 | Biological process | peripheral nervous system myelin formation |
| GO_0043589 | Biological process | skin morphogenesis |
| GO_0046847 | Biological process | filopodium assembly |
| GO_0031581 | Biological process | hemidesmosome assembly |
| GO_0006914 | Biological process | autophagy |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0009611 | Biological process | response to wounding |
| GO_0016477 | Biological process | cell migration |
| GO_0005730 | Cellular component | nucleolus |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008305 | Cellular component | integrin complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0009925 | Cellular component | basal plasma membrane |
| GO_0031252 | Cellular component | cell leading edge |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0030056 | Cellular component | hemidesmosome |
| GO_0009986 | Cellular component | cell surface |
| GO_0005604 | Cellular component | basement membrane |
| GO_0030054 | Cellular component | cell junction |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0031994 | Molecular function | insulin-like growth factor I binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0001664 | Molecular function | G protein-coupled receptor binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0038132 | Molecular function | neuregulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ITGB4 |
| Protein name | Integrin beta-4 (GP150) (CD antigen CD104) Integrin beta Integrin subunit beta 4 |
| Synonyms | |
| Description | FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling . ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling . . |
| Accessions | J3QQL2 ENST00000582629.1 P16144 Q2VP98 ENST00000449880.7 [P16144-3] J3KSH9 B7ZLD5 ENST00000578318.1 ENST00000200181.8 [P16144-1] ENST00000450894.7 [P16144-2] ENST00000579662.5 [P16144-2] B7ZLD8 ENST00000584939.1 J3QRK0 |