ITGB4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ITGB4 at tissue level.

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0033627Biological processcell adhesion mediated by integrin
GO_0007160Biological processcell-matrix adhesion
GO_0035878Biological processnail development
GO_0007155Biological processcell adhesion
GO_0048333Biological processmesodermal cell differentiation
GO_0061450Biological processtrophoblast cell migration
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0032290Biological processperipheral nervous system myelin formation
GO_0043589Biological processskin morphogenesis
GO_0046847Biological processfilopodium assembly
GO_0031581Biological processhemidesmosome assembly
GO_0006914Biological processautophagy
GO_0098609Biological processcell-cell adhesion
GO_0009611Biological processresponse to wounding
GO_0016477Biological processcell migration
GO_0005730Cellular componentnucleolus
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0008305Cellular componentintegrin complex
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0031252Cellular componentcell leading edge
GO_0005925Cellular componentfocal adhesion
GO_0030056Cellular componenthemidesmosome
GO_0009986Cellular componentcell surface
GO_0005604Cellular componentbasement membrane
GO_0030054Cellular componentcell junction
GO_0031965Cellular componentnuclear membrane
GO_0031994Molecular functioninsulin-like growth factor I binding
GO_0005178Molecular functionintegrin binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0038132Molecular functionneuregulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameITGB4
Protein nameIntegrin beta-4 (GP150) (CD antigen CD104)
Integrin beta
Integrin subunit beta 4
Synonyms
DescriptionFUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling . ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling . .

AccessionsJ3QQL2
ENST00000582629.1
P16144
Q2VP98
ENST00000449880.7 [P16144-3]
J3KSH9
B7ZLD5
ENST00000578318.1
ENST00000200181.8 [P16144-1]
ENST00000450894.7 [P16144-2]
ENST00000579662.5 [P16144-2]
B7ZLD8
ENST00000584939.1
J3QRK0