IL16 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	30 studies	28% ± 10%	Explore
natural killer cell	28 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	24 studies	31% ± 15%	Explore
CD4-positive, alpha-beta T cell	21 studies	33% ± 15%	Explore
naive B cell	18 studies	31% ± 9%	Explore
memory B cell	17 studies	32% ± 9%	Explore
regulatory T cell	16 studies	35% ± 15%	Explore
gamma-delta T cell	15 studies	27% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	30% ± 12%	Explore
T cell	13 studies	30% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	32% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	34% ± 18%	Explore
plasmacytoid dendritic cell	11 studies	34% ± 9%	Explore
mature NK T cell	11 studies	37% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	29% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 10%	Explore
conventional dendritic cell	10 studies	25% ± 10%	Explore
mucosal invariant T cell	9 studies	32% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	30% ± 12%	Explore
non-classical monocyte	7 studies	21% ± 7%	Explore
plasma cell	6 studies	24% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	32% ± 8%	Explore
dendritic cell	6 studies	33% ± 15%	Explore
T follicular helper cell	6 studies	33% ± 8%	Explore
innate lymphoid cell	6 studies	24% ± 9%	Explore
fibroblast	6 studies	22% ± 4%	Explore
exhausted T cell	5 studies	35% ± 3%	Explore
macrophage	5 studies	18% ± 4%	Explore
plasmablast	4 studies	24% ± 7%	Explore
precursor B cell	4 studies	30% ± 9%	Explore
immature B cell	4 studies	27% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	31% ± 4%	Explore
adipocyte	4 studies	26% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 7%	Explore
glutamatergic neuron	3 studies	27% ± 8%	Explore
classical monocyte	3 studies	26% ± 2%	Explore
T-helper 17 cell	3 studies	36% ± 23%	Explore
intraepithelial lymphocyte	3 studies	31% ± 12%	Explore
germinal center B cell	3 studies	31% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	32% ± 5%	Explore
ciliated cell	3 studies	33% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 8%	Explore
double negative thymocyte	3 studies	27% ± 9%	Explore
microglial cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	25% ± 4%	Explore
adipose	3 studies	20% ± 3%	Explore
brain	3 studies	20% ± 3%	Explore
lymph node	3 studies	35% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	98%	2736.34	450 / 459	94%	5.34	1053 / 1118
lung	100%	3897.05	576 / 578	92%	4.65	1059 / 1155
skin	78%	1600.33	1412 / 1809	99%	13.97	467 / 472
uterus	94%	1986.04	160 / 170	71%	2.12	324 / 459
thymus	78%	1088.69	508 / 653	86%	5.99	518 / 605
esophagus	85%	1459.05	1231 / 1445	74%	2.14	135 / 183
bladder	95%	2006.62	20 / 21	64%	2.16	321 / 504
intestine	81%	1933.07	787 / 966	67%	2.57	351 / 527
stomach	73%	944.32	261 / 359	74%	2.83	213 / 286
prostate	68%	848.32	167 / 245	70%	1.78	349 / 502
ovary	59%	930.11	106 / 180	69%	1.82	295 / 430
brain	24%	1974.29	625 / 2642	79%	2.45	559 / 705
lymph node	0%	0	0 / 0	100%	49.82	29 / 29
spleen	100%	8346.05	241 / 241	0%	0	0 / 0
peripheral blood	100%	9501.28	927 / 929	0%	0	0 / 0
adipose	99%	2970.82	1193 / 1204	0%	0	0 / 0
kidney	13%	209.08	12 / 89	85%	4.37	764 / 901
pancreas	4%	37.27	14 / 328	87%	5.79	155 / 178
tonsil	0%	0	0 / 0	87%	6.37	39 / 45
eye	0%	0	0 / 0	85%	3.49	68 / 80
adrenal gland	40%	352.53	103 / 258	39%	0.76	89 / 230
blood vessel	73%	1034.36	977 / 1335	0%	0	0 / 0
liver	9%	75.84	21 / 226	54%	1.50	220 / 406
heart	31%	305.77	263 / 861	0%	0	0 / 0
muscle	11%	98.26	87 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0006955	Biological process	immune response
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0032730	Biological process	positive regulation of interleukin-1 alpha production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0050930	Biological process	induction of positive chemotaxis
GO_0030595	Biological process	leukocyte chemotaxis
GO_0051924	Biological process	regulation of calcium ion transport
GO_0016607	Cellular component	nuclear speck
GO_0005615	Cellular component	extracellular space
GO_0090543	Cellular component	Flemming body
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005925	Cellular component	focal adhesion
GO_0042609	Molecular function	CD4 receptor binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	IL16
Protein name	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 protein Interleukin 16
Synonyms
Description	FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. . FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. .
Accessions	Q9UME6 Q14005 ENST00000558857.5 A0A8C8KBU6 Q05BE6 ENST00000394652.6 [Q14005-3] Q6ZTT5 ENST00000560115.5 H0YKB7 H0YLL1 Q8IUU6 H0YLH9 I7GGY3 ENST00000360547.9 H3BN12 Q53HR8 ENST00000683961.1 [Q14005-1] H0YLB1 B7Z8M3 H3BT15 ENST00000706926.1 [Q14005-2] ENST00000302987.10 ENST00000394660.6 [Q14005-2] ENST00000559383.5 ENST00000558332.3 B3KY62 ENST00000560241.5

IL16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review