DST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0030011Biological processmaintenance of cell polarity
GO_0008090Biological processretrograde axonal transport
GO_0007155Biological processcell adhesion
GO_0007010Biological processcytoskeleton organization
GO_0042060Biological processwound healing
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0045104Biological processintermediate filament cytoskeleton organization
GO_0031581Biological processhemidesmosome assembly
GO_0009611Biological processresponse to wounding
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030018Cellular componentZ disc
GO_0035371Cellular componentmicrotubule plus-end
GO_0005654Cellular componentnucleoplasm
GO_0009925Cellular componentbasal plasma membrane
GO_0005635Cellular componentnuclear envelope
GO_0031252Cellular componentcell leading edge
GO_0005882Cellular componentintermediate filament
GO_0005925Cellular componentfocal adhesion
GO_0030056Cellular componenthemidesmosome
GO_0001725Cellular componentstress fiber
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005604Cellular componentbasement membrane
GO_0031673Cellular componentH zone
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0005198Molecular functionstructural molecule activity
GO_0005178Molecular functionintegrin binding
GO_0008017Molecular functionmicrotubule binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameDST
Protein nameDystonin
Alternative protein DST
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
DST protein
DST protein (Dystonin)
SynonymsBP240
KIAA0728
DT
DMH
BP230
BPAG1
DescriptionFUNCTION: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). .; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. .; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.

AccessionsENST00000361203.7
F6QMI7
ENST00000522360.5
Q03001
ENST00000370788.6 [Q03001-14]
A0A494C1U5
A0A7P0T890
F8W9J4
Q86T18
ENST00000312431.10
ENST00000523943.1
E7ERX3
ENST00000680361.1
ENST00000523817.1
H0YC65
ENST00000518398.2
A0A494C073
ENST00000651790.1
ENST00000651289.1
Q9BSP9
ENST00000340834.10
ENST00000370765.11 [Q03001-3]
E9PHM6
ENST00000421834.7
L8E8Z4
E7ETB9
ENST00000518935.5
Q6P0N6
ENST00000449297.7
H0YAT7
H0YBX0
A0A0U1RQJ2
Q5T0V7
ENST00000244364.10 [Q03001-8]
ENST00000523292.5
A0A494C1D7
ENST00000439203.5 [Q03001-9]
H0YC82
ENST00000520645.6
ENST00000652573.1