Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 44 studies | 50% ± 21% | |
endothelial cell | 36 studies | 39% ± 18% | |
pericyte | 33 studies | 42% ± 17% | |
smooth muscle cell | 32 studies | 44% ± 16% | |
macrophage | 23 studies | 35% ± 15% | |
basal cell | 23 studies | 50% ± 21% | |
endothelial cell of lymphatic vessel | 22 studies | 46% ± 17% | |
astrocyte | 22 studies | 79% ± 16% | |
oligodendrocyte | 17 studies | 83% ± 18% | |
oligodendrocyte precursor cell | 17 studies | 75% ± 14% | |
microglial cell | 17 studies | 50% ± 18% | |
myofibroblast cell | 14 studies | 45% ± 16% | |
epithelial cell | 14 studies | 37% ± 15% | |
glutamatergic neuron | 13 studies | 76% ± 17% | |
endothelial cell of artery | 13 studies | 34% ± 13% | |
type I pneumocyte | 11 studies | 61% ± 15% | |
connective tissue cell | 11 studies | 39% ± 11% | |
GABAergic neuron | 11 studies | 79% ± 15% | |
neuron | 10 studies | 66% ± 12% | |
adipocyte | 10 studies | 41% ± 14% | |
mesothelial cell | 10 studies | 45% ± 12% | |
dendritic cell | 9 studies | 35% ± 12% | |
retinal cone cell | 9 studies | 85% ± 19% | |
capillary endothelial cell | 9 studies | 30% ± 14% | |
myeloid cell | 9 studies | 30% ± 13% | |
alveolar macrophage | 8 studies | 34% ± 15% | |
amacrine cell | 8 studies | 56% ± 16% | |
glial cell | 8 studies | 63% ± 22% | |
ciliated cell | 8 studies | 27% ± 13% | |
interneuron | 7 studies | 75% ± 19% | |
retinal ganglion cell | 7 studies | 93% ± 8% | |
endothelial cell of vascular tree | 7 studies | 37% ± 19% | |
conventional dendritic cell | 7 studies | 22% ± 7% | |
mast cell | 7 studies | 25% ± 10% | |
progenitor cell | 6 studies | 37% ± 17% | |
enterocyte | 6 studies | 26% ± 5% | |
goblet cell | 6 studies | 33% ± 23% | |
Schwann cell | 6 studies | 79% ± 9% | |
vein endothelial cell | 6 studies | 31% ± 7% | |
retina horizontal cell | 6 studies | 70% ± 15% | |
retinal rod cell | 6 studies | 32% ± 20% | |
cardiac muscle cell | 6 studies | 75% ± 20% | |
Mueller cell | 6 studies | 70% ± 14% | |
secretory cell | 6 studies | 18% ± 2% | |
ionocyte | 5 studies | 72% ± 10% | |
hepatocyte | 5 studies | 74% ± 22% | |
podocyte | 5 studies | 65% ± 31% | |
abnormal cell | 5 studies | 42% ± 21% | |
retinal bipolar neuron | 5 studies | 74% ± 6% | |
OFF-bipolar cell | 5 studies | 81% ± 23% | |
ON-bipolar cell | 5 studies | 79% ± 26% | |
kidney loop of Henle epithelial cell | 5 studies | 25% ± 6% | |
adventitial cell | 5 studies | 51% ± 12% | |
melanocyte | 5 studies | 48% ± 19% | |
keratinocyte | 5 studies | 44% ± 9% | |
pancreatic A cell | 4 studies | 53% ± 17% | |
cholangiocyte | 4 studies | 60% ± 17% | |
granule cell | 4 studies | 73% ± 14% | |
mononuclear phagocyte | 4 studies | 26% ± 10% | |
muscle cell | 4 studies | 47% ± 6% | |
myoepithelial cell | 4 studies | 90% ± 5% | |
hillock cell | 3 studies | 30% ± 10% | |
precursor cell | 3 studies | 70% ± 11% | |
pancreatic D cell | 3 studies | 49% ± 25% | |
type B pancreatic cell | 3 studies | 62% ± 22% | |
hepatic stellate cell | 3 studies | 60% ± 19% | |
T cell | 3 studies | 31% ± 12% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 87% ± 4% | |
neural crest cell | 3 studies | 46% ± 19% | |
GABAergic interneuron | 3 studies | 81% ± 7% | |
Purkinje cell | 3 studies | 70% ± 17% | |
lymphocyte | 3 studies | 39% ± 12% | |
GABAergic amacrine cell | 3 studies | 57% ± 16% | |
glycinergic amacrine cell | 3 studies | 59% ± 3% | |
rod bipolar cell | 3 studies | 74% ± 10% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 24% ± 12% | |
pancreatic ductal cell | 3 studies | 74% ± 19% | |
neural progenitor cell | 3 studies | 69% ± 16% | |
ependymal cell | 3 studies | 80% ± 5% | |
enteroendocrine cell | 3 studies | 27% ± 12% | |
chondrocyte | 3 studies | 48% ± 16% | |
monocyte | 3 studies | 45% ± 21% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 28% ± 6% | |
parietal epithelial cell | 3 studies | 50% ± 9% | |
renal alpha-intercalated cell | 3 studies | 36% ± 13% | |
mucus secreting cell | 3 studies | 41% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 20 studies | 70% ± 20% | |
lung | 13 studies | 32% ± 10% | |
eye | 11 studies | 46% ± 17% | |
intestine | 7 studies | 28% ± 11% | |
heart | 6 studies | 50% ± 20% | |
pancreas | 4 studies | 49% ± 22% | |
prostate | 4 studies | 41% ± 7% | |
adipose | 4 studies | 45% ± 21% | |
kidney | 4 studies | 29% ± 7% | |
liver | 3 studies | 49% ± 19% | |
uterus | 3 studies | 29% ± 10% | |
breast | 3 studies | 32% ± 11% | |
skin | 3 studies | 36% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 29727.12 | 2640 / 2642 | 99% | 41.93 | 700 / 705 |
esophagus | 99% | 30397.36 | 1434 / 1445 | 97% | 39.10 | 177 / 183 |
adrenal gland | 100% | 21744.65 | 258 / 258 | 93% | 16.65 | 215 / 230 |
skin | 100% | 49426.37 | 1809 / 1809 | 88% | 16.77 | 416 / 472 |
breast | 100% | 36601.07 | 457 / 459 | 88% | 15.75 | 983 / 1118 |
uterus | 100% | 41655.47 | 170 / 170 | 82% | 20.59 | 378 / 459 |
lung | 100% | 31112.17 | 576 / 578 | 82% | 22.08 | 951 / 1155 |
prostate | 100% | 26537.49 | 244 / 245 | 82% | 9.75 | 412 / 502 |
bladder | 100% | 25860.95 | 21 / 21 | 77% | 12.62 | 389 / 504 |
kidney | 90% | 9550.42 | 80 / 89 | 87% | 10.18 | 780 / 901 |
intestine | 99% | 33394.59 | 958 / 966 | 74% | 8.05 | 391 / 527 |
liver | 94% | 10546.60 | 212 / 226 | 72% | 8.54 | 294 / 406 |
stomach | 88% | 14297.40 | 316 / 359 | 72% | 8.99 | 206 / 286 |
thymus | 89% | 8581.79 | 579 / 653 | 65% | 6.85 | 392 / 605 |
pancreas | 33% | 2501.19 | 108 / 328 | 96% | 15.38 | 171 / 178 |
ovary | 100% | 22321.23 | 180 / 180 | 17% | 1.07 | 71 / 430 |
blood vessel | 100% | 36550.30 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 25372.40 | 802 / 803 | 0% | 0 | 0 / 0 |
adipose | 99% | 17013.84 | 1189 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 36.41 | 44 / 45 |
heart | 96% | 25733.96 | 827 / 861 | 0% | 0 | 0 / 0 |
spleen | 84% | 7855.55 | 202 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 20% | 1.54 | 16 / 80 |
peripheral blood | 17% | 2742.45 | 154 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 14% | 1.23 | 4 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048870 | Biological process | cell motility |
GO_0030011 | Biological process | maintenance of cell polarity |
GO_0008090 | Biological process | retrograde axonal transport |
GO_0007155 | Biological process | cell adhesion |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0042060 | Biological process | wound healing |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0045104 | Biological process | intermediate filament cytoskeleton organization |
GO_0031581 | Biological process | hemidesmosome assembly |
GO_0009611 | Biological process | response to wounding |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0030018 | Cellular component | Z disc |
GO_0035371 | Cellular component | microtubule plus-end |
GO_0005654 | Cellular component | nucleoplasm |
GO_0009925 | Cellular component | basal plasma membrane |
GO_0005635 | Cellular component | nuclear envelope |
GO_0031252 | Cellular component | cell leading edge |
GO_0005882 | Cellular component | intermediate filament |
GO_0005925 | Cellular component | focal adhesion |
GO_0030056 | Cellular component | hemidesmosome |
GO_0001725 | Cellular component | stress fiber |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0005604 | Cellular component | basement membrane |
GO_0031673 | Cellular component | H zone |
GO_1904115 | Cellular component | axon cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0051010 | Molecular function | microtubule plus-end binding |
GO_0005198 | Molecular function | structural molecule activity |
GO_0005178 | Molecular function | integrin binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | DST |
Protein name | Dystonin Alternative protein DST Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST protein DST protein (Dystonin) |
Synonyms | BP240 KIAA0728 DT DMH BP230 BPAG1 |
Description | FUNCTION: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). .; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. .; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
Accessions | ENST00000361203.7 F6QMI7 ENST00000522360.5 Q03001 ENST00000370788.6 [Q03001-14] A0A494C1U5 A0A7P0T890 F8W9J4 Q86T18 ENST00000312431.10 ENST00000523943.1 E7ERX3 ENST00000680361.1 ENST00000523817.1 H0YC65 ENST00000518398.2 A0A494C073 ENST00000651790.1 ENST00000651289.1 Q9BSP9 ENST00000340834.10 ENST00000370765.11 [Q03001-3] E9PHM6 ENST00000421834.7 L8E8Z4 E7ETB9 ENST00000518935.5 Q6P0N6 ENST00000449297.7 H0YAT7 H0YBX0 A0A0U1RQJ2 Q5T0V7 ENST00000244364.10 [Q03001-8] ENST00000523292.5 A0A494C1D7 ENST00000439203.5 [Q03001-9] H0YC82 ENST00000520645.6 ENST00000652573.1 |