ATP6V0C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048388Biological processendosomal lumen acidification
GO_0015986Biological processproton motive force-driven ATP synthesis
GO_0007042Biological processlysosomal lumen acidification
GO_0051452Biological processintracellular pH reduction
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0007035Biological processvacuolar acidification
GO_0061795Biological processGolgi lumen acidification
GO_0016241Biological processregulation of macroautophagy
GO_1902600Biological processproton transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1902495Cellular componenttransmembrane transporter complex
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0070821Cellular componenttertiary granule membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0000220Cellular componentvacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0046933Molecular functionproton-transporting ATP synthase activity, rotational mechanism
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V0C
Protein nameV-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)
ATPase H+ transporting V0 subunit c
V-type proton ATPase proteolipid subunit
SynonymsATP6C
ATP6L
hCG_1780666
ATPL
DescriptionFUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). .

FUNCTION: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. .

AccessionsENST00000330398.9
P27449
H3BMY0
ENST00000564973.1
ENST00000568562.1
ENST00000565223.1
H3BNI4