MARCKS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0051017Biological processactin filament bundle assembly
GO_0007005Biological processmitochondrion organization
GO_0022008Biological processneurogenesis
GO_0051764Biological processactin crosslink formation
GO_0007015Biological processactin filament organization
GO_0007417Biological processcentral nervous system development
GO_0006915Biological processapoptotic process
GO_0021915Biological processneural tube development
GO_0042585Cellular componentgerminal vesicle
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0015629Cellular componentactin cytoskeleton
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0032432Cellular componentactin filament bundle
GO_0005080Molecular functionprotein kinase C binding
GO_0051015Molecular functionactin filament binding
GO_0042802Molecular functionidentical protein binding
GO_0005516Molecular functioncalmodulin binding

IV. Literature review

[source]
Gene nameMARCKS
Protein nameMyristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Myristoylated alanine-rich C-kinase substrate
SynonymsMACS
PRKCSL
DescriptionFUNCTION: Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes . Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis . During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages . Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). .

FUNCTION: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. .

FUNCTION: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. .

AccessionsQ05C82
ENST00000612661.2
Q6NVI1
P29966