Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 37 studies | 52% ± 24% | |
endothelial cell | 33 studies | 44% ± 22% | |
fibroblast | 32 studies | 48% ± 21% | |
classical monocyte | 22 studies | 40% ± 22% | |
B cell | 21 studies | 30% ± 12% | |
endothelial cell of lymphatic vessel | 21 studies | 62% ± 23% | |
non-classical monocyte | 21 studies | 48% ± 21% | |
pericyte | 20 studies | 48% ± 26% | |
monocyte | 17 studies | 40% ± 16% | |
smooth muscle cell | 16 studies | 38% ± 19% | |
ciliated cell | 16 studies | 45% ± 19% | |
connective tissue cell | 15 studies | 45% ± 24% | |
astrocyte | 15 studies | 34% ± 19% | |
oligodendrocyte precursor cell | 15 studies | 49% ± 24% | |
conventional dendritic cell | 15 studies | 33% ± 11% | |
microglial cell | 15 studies | 42% ± 18% | |
dendritic cell | 14 studies | 49% ± 23% | |
epithelial cell | 14 studies | 49% ± 19% | |
capillary endothelial cell | 13 studies | 33% ± 14% | |
memory B cell | 13 studies | 31% ± 11% | |
basal cell | 13 studies | 42% ± 19% | |
myofibroblast cell | 11 studies | 43% ± 19% | |
vein endothelial cell | 11 studies | 39% ± 21% | |
myeloid cell | 11 studies | 53% ± 22% | |
neutrophil | 9 studies | 50% ± 17% | |
endothelial cell of vascular tree | 9 studies | 32% ± 9% | |
secretory cell | 9 studies | 43% ± 19% | |
glutamatergic neuron | 8 studies | 37% ± 15% | |
progenitor cell | 8 studies | 38% ± 16% | |
neuron | 8 studies | 47% ± 24% | |
naive B cell | 7 studies | 24% ± 8% | |
plasma cell | 6 studies | 29% ± 9% | |
endothelial cell of artery | 6 studies | 31% ± 14% | |
GABAergic neuron | 6 studies | 36% ± 14% | |
abnormal cell | 6 studies | 46% ± 22% | |
leukocyte | 6 studies | 46% ± 10% | |
mesothelial cell | 6 studies | 59% ± 22% | |
amacrine cell | 6 studies | 42% ± 20% | |
retinal ganglion cell | 6 studies | 74% ± 25% | |
ionocyte | 5 studies | 32% ± 24% | |
interneuron | 5 studies | 40% ± 13% | |
goblet cell | 5 studies | 44% ± 12% | |
glial cell | 5 studies | 44% ± 23% | |
Mueller cell | 5 studies | 43% ± 15% | |
squamous epithelial cell | 4 studies | 41% ± 21% | |
transit amplifying cell | 4 studies | 43% ± 16% | |
retinal bipolar neuron | 4 studies | 41% ± 8% | |
GABAergic amacrine cell | 4 studies | 39% ± 6% | |
retina horizontal cell | 4 studies | 40% ± 15% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 45% ± 7% | |
deuterosomal cell | 3 studies | 31% ± 1% | |
mononuclear phagocyte | 3 studies | 50% ± 17% | |
T cell | 3 studies | 31% ± 20% | |
enterocyte | 3 studies | 26% ± 5% | |
enteroendocrine cell | 3 studies | 43% ± 17% | |
intestinal crypt stem cell | 3 studies | 38% ± 3% | |
neural crest cell | 3 studies | 83% ± 7% | |
granule cell | 3 studies | 32% ± 14% | |
glycinergic amacrine cell | 3 studies | 28% ± 8% | |
immature B cell | 3 studies | 28% ± 9% | |
pro-B cell | 3 studies | 25% ± 3% | |
retinal cone cell | 3 studies | 30% ± 14% | |
tissue-resident macrophage | 3 studies | 60% ± 25% | |
rod bipolar cell | 3 studies | 41% ± 19% | |
inflammatory macrophage | 3 studies | 44% ± 16% | |
acinar cell | 3 studies | 53% ± 29% | |
myoepithelial cell | 3 studies | 49% ± 30% | |
luminal cell of prostate epithelium | 3 studies | 43% ± 5% | |
OFF-bipolar cell | 3 studies | 63% ± 23% | |
ON-bipolar cell | 3 studies | 60% ± 22% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 15 studies | 34% ± 15% | |
lung | 11 studies | 41% ± 21% | |
intestine | 7 studies | 42% ± 20% | |
eye | 7 studies | 35% ± 15% | |
peripheral blood | 5 studies | 24% ± 4% | |
kidney | 4 studies | 27% ± 13% | |
placenta | 4 studies | 33% ± 21% | |
uterus | 4 studies | 35% ± 11% | |
breast | 4 studies | 31% ± 7% | |
pancreas | 3 studies | 46% ± 29% | |
prostate | 3 studies | 47% ± 10% | |
adipose | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 11110.18 | 2641 / 2642 | 100% | 693.89 | 704 / 705 |
pancreas | 100% | 5484.20 | 327 / 328 | 99% | 168.51 | 177 / 178 |
bladder | 100% | 8052.38 | 21 / 21 | 99% | 225.29 | 497 / 504 |
prostate | 100% | 6567.85 | 244 / 245 | 99% | 156.84 | 495 / 502 |
lung | 100% | 8101.21 | 577 / 578 | 98% | 166.75 | 1131 / 1155 |
breast | 99% | 6103.45 | 455 / 459 | 99% | 188.52 | 1102 / 1118 |
esophagus | 98% | 5833.52 | 1417 / 1445 | 99% | 160.34 | 182 / 183 |
uterus | 98% | 4275.09 | 167 / 170 | 99% | 224.67 | 453 / 459 |
stomach | 100% | 5612.33 | 359 / 359 | 97% | 129.41 | 277 / 286 |
intestine | 100% | 8804.42 | 966 / 966 | 97% | 134.71 | 510 / 527 |
skin | 100% | 8709.21 | 1800 / 1809 | 96% | 178.76 | 454 / 472 |
ovary | 100% | 5377.17 | 180 / 180 | 90% | 100.46 | 385 / 430 |
thymus | 99% | 4027.67 | 645 / 653 | 81% | 78.68 | 488 / 605 |
kidney | 87% | 3129.00 | 77 / 89 | 89% | 135.14 | 805 / 901 |
adrenal gland | 70% | 1710.83 | 181 / 258 | 75% | 78.52 | 173 / 230 |
liver | 42% | 971.73 | 94 / 226 | 61% | 59.25 | 247 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 147.75 | 29 / 29 |
spleen | 100% | 9069.87 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 171.20 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 110.08 | 1 / 1 |
adipose | 99% | 5639.54 | 1190 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 9403.09 | 907 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 132.27 | 73 / 80 |
blood vessel | 90% | 3373.30 | 1199 / 1335 | 0% | 0 | 0 / 0 |
heart | 76% | 2286.72 | 653 / 861 | 0% | 0 | 0 / 0 |
muscle | 14% | 282.80 | 110 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0051017 | Biological process | actin filament bundle assembly |
GO_0007005 | Biological process | mitochondrion organization |
GO_0022008 | Biological process | neurogenesis |
GO_0051764 | Biological process | actin crosslink formation |
GO_0007015 | Biological process | actin filament organization |
GO_0007417 | Biological process | central nervous system development |
GO_0006915 | Biological process | apoptotic process |
GO_0021915 | Biological process | neural tube development |
GO_0042585 | Cellular component | germinal vesicle |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005925 | Cellular component | focal adhesion |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005938 | Cellular component | cell cortex |
GO_0005737 | Cellular component | cytoplasm |
GO_0032432 | Cellular component | actin filament bundle |
GO_0005080 | Molecular function | protein kinase C binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0005516 | Molecular function | calmodulin binding |
Gene name | MARCKS |
Protein name | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) Myristoylated alanine-rich C-kinase substrate |
Synonyms | MACS PRKCSL |
Description | FUNCTION: Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes . Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis . During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages . Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). . FUNCTION: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. . FUNCTION: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. . |
Accessions | Q05C82 ENST00000612661.2 Q6NVI1 P29966 |