PPP1R12A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	37% ± 15%	Explore
pericyte	40 studies	53% ± 17%	Explore
natural killer cell	35 studies	35% ± 9%	Explore
fibroblast	35 studies	30% ± 10%	Explore
B cell	34 studies	26% ± 7%	Explore
smooth muscle cell	33 studies	58% ± 15%	Explore
CD8-positive, alpha-beta T cell	31 studies	28% ± 9%	Explore
macrophage	30 studies	29% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	24% ± 7%	Explore
T cell	27 studies	28% ± 9%	Explore
regulatory T cell	24 studies	31% ± 7%	Explore
classical monocyte	21 studies	24% ± 9%	Explore
mature NK T cell	20 studies	29% ± 8%	Explore
mast cell	19 studies	26% ± 11%	Explore
non-classical monocyte	19 studies	27% ± 10%	Explore
monocyte	18 studies	29% ± 14%	Explore
conventional dendritic cell	18 studies	25% ± 12%	Explore
memory B cell	18 studies	22% ± 4%	Explore
astrocyte	17 studies	43% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	35% ± 9%	Explore
naive B cell	16 studies	24% ± 5%	Explore
oligodendrocyte precursor cell	16 studies	53% ± 21%	Explore
gamma-delta T cell	16 studies	33% ± 10%	Explore
endothelial cell of lymphatic vessel	15 studies	27% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	37% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	23% ± 6%	Explore
capillary endothelial cell	15 studies	29% ± 10%	Explore
myofibroblast cell	15 studies	47% ± 16%	Explore
microglial cell	15 studies	43% ± 15%	Explore
dendritic cell	14 studies	36% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	25% ± 6%	Explore
connective tissue cell	13 studies	36% ± 14%	Explore
endothelial cell of artery	13 studies	28% ± 10%	Explore
mucosal invariant T cell	13 studies	26% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 8%	Explore
glutamatergic neuron	12 studies	56% ± 25%	Explore
oligodendrocyte	12 studies	37% ± 13%	Explore
basal cell	12 studies	31% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	26% ± 5%	Explore
GABAergic neuron	11 studies	44% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	34% ± 7%	Explore
vein endothelial cell	11 studies	26% ± 6%	Explore
epithelial cell	11 studies	37% ± 19%	Explore
plasmacytoid dendritic cell	11 studies	24% ± 8%	Explore
myeloid cell	11 studies	34% ± 12%	Explore
endothelial cell of vascular tree	11 studies	30% ± 17%	Explore
type I pneumocyte	10 studies	26% ± 9%	Explore
neuron	9 studies	42% ± 16%	Explore
mesothelial cell	9 studies	39% ± 15%	Explore
adipocyte	9 studies	29% ± 10%	Explore
leukocyte	8 studies	40% ± 16%	Explore
abnormal cell	8 studies	30% ± 14%	Explore
type II pneumocyte	7 studies	24% ± 6%	Explore
ciliated cell	7 studies	25% ± 9%	Explore
neutrophil	6 studies	24% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	31% ± 7%	Explore
mononuclear phagocyte	6 studies	31% ± 13%	Explore
progenitor cell	6 studies	27% ± 5%	Explore
interneuron	6 studies	53% ± 21%	Explore
lymphocyte	6 studies	34% ± 9%	Explore
precursor B cell	6 studies	33% ± 12%	Explore
club cell	6 studies	28% ± 9%	Explore
amacrine cell	6 studies	32% ± 8%	Explore
retina horizontal cell	6 studies	29% ± 9%	Explore
T follicular helper cell	6 studies	25% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	30% ± 7%	Explore
hematopoietic precursor cell	5 studies	41% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	31% ± 5%	Explore
retinal bipolar neuron	5 studies	24% ± 5%	Explore
glial cell	5 studies	31% ± 8%	Explore
hematopoietic stem cell	5 studies	29% ± 13%	Explore
pro-B cell	5 studies	36% ± 8%	Explore
retinal rod cell	5 studies	22% ± 5%	Explore
cardiac muscle cell	5 studies	37% ± 3%	Explore
Mueller cell	5 studies	24% ± 10%	Explore
respiratory goblet cell	5 studies	29% ± 9%	Explore
innate lymphoid cell	5 studies	32% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	29% ± 5%	Explore
exhausted T cell	4 studies	40% ± 12%	Explore
granule cell	4 studies	42% ± 10%	Explore
retinal ganglion cell	4 studies	35% ± 8%	Explore
plasma cell	4 studies	28% ± 10%	Explore
immature B cell	4 studies	30% ± 5%	Explore
retinal cone cell	4 studies	21% ± 4%	Explore
secretory cell	4 studies	25% ± 4%	Explore
enteroendocrine cell	4 studies	24% ± 7%	Explore
goblet cell	4 studies	22% ± 1%	Explore
alveolar macrophage	4 studies	38% ± 16%	Explore
T-helper 17 cell	4 studies	21% ± 6%	Explore
myoepithelial cell	4 studies	53% ± 20%	Explore
plasmablast	3 studies	39% ± 16%	Explore
glomerular endothelial cell	3 studies	26% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	20% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	42% ± 5%	Explore
neural crest cell	3 studies	23% ± 2%	Explore
GABAergic interneuron	3 studies	38% ± 5%	Explore
megakaryocyte	3 studies	42% ± 25%	Explore
retinal pigment epithelial cell	3 studies	30% ± 17%	Explore
GABAergic amacrine cell	3 studies	33% ± 6%	Explore
OFF-bipolar cell	3 studies	25% ± 4%	Explore
ON-bipolar cell	3 studies	28% ± 5%	Explore
glycinergic amacrine cell	3 studies	30% ± 2%	Explore
rod bipolar cell	3 studies	30% ± 5%	Explore
germinal center B cell	3 studies	22% ± 4%	Explore
CD4-positive helper T cell	3 studies	27% ± 5%	Explore
hepatocyte	3 studies	36% ± 20%	Explore
muscle cell	3 studies	67% ± 25%	Explore
ependymal cell	3 studies	41% ± 16%	Explore
granulocyte	3 studies	32% ± 19%	Explore
adventitial cell	3 studies	27% ± 5%	Explore
chondrocyte	3 studies	28% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 12%	Explore
Schwann cell	3 studies	28% ± 4%	Explore
transit amplifying cell	3 studies	40% ± 33%	Explore
T-helper 1 cell	3 studies	26% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 4%	Explore
double negative thymocyte	3 studies	42% ± 12%	Explore
mural cell	3 studies	58% ± 2%	Explore
mucus secreting cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	44% ± 20%	Explore
lung	16 studies	28% ± 9%	Explore
peripheral blood	16 studies	28% ± 9%	Explore
eye	9 studies	26% ± 10%	Explore
intestine	7 studies	25% ± 10%	Explore
kidney	6 studies	27% ± 5%	Explore
heart	5 studies	32% ± 5%	Explore
lymph node	5 studies	22% ± 3%	Explore
liver	5 studies	37% ± 14%	Explore
bone marrow	4 studies	33% ± 15%	Explore
uterus	4 studies	35% ± 11%	Explore
breast	4 studies	22% ± 6%	Explore
adipose	4 studies	36% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	14322.27	1444 / 1445	100%	26.72	183 / 183
lung	99%	6075.37	575 / 578	100%	20.51	1153 / 1155
breast	100%	6197.05	459 / 459	99%	22.01	1109 / 1118
prostate	100%	7672.26	244 / 245	100%	23.30	500 / 502
bladder	100%	13841.86	21 / 21	99%	17.19	497 / 504
thymus	100%	5389.43	652 / 653	99%	18.91	597 / 605
ovary	100%	5270.71	180 / 180	98%	13.38	423 / 430
uterus	100%	11473.84	170 / 170	98%	21.50	451 / 459
intestine	100%	11501.45	966 / 966	98%	16.49	515 / 527
adrenal gland	98%	2841.89	253 / 258	93%	13.18	215 / 230
skin	99%	5159.91	1798 / 1809	90%	16.32	426 / 472
stomach	91%	5942.93	328 / 359	98%	19.30	280 / 286
brain	90%	2610.20	2366 / 2642	100%	22.12	702 / 705
kidney	80%	2153.51	71 / 89	95%	15.90	855 / 901
pancreas	34%	642.91	111 / 328	98%	16.66	175 / 178
blood vessel	100%	15031.45	1335 / 1335	0%	0	0 / 0
spleen	100%	5081.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.56	45 / 45
ureter	0%	0	0 / 0	100%	6.09	1 / 1
adipose	100%	6627.53	1201 / 1204	0%	0	0 / 0
muscle	97%	2947.54	777 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	19.02	28 / 29
liver	27%	490.65	61 / 226	65%	5.67	262 / 406
heart	87%	2744.94	749 / 861	0%	0	0 / 0
peripheral blood	77%	4369.51	711 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	5.09	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0006470	Biological process	protein dephosphorylation
GO_0000278	Biological process	mitotic cell cycle
GO_0007165	Biological process	signal transduction
GO_0035507	Biological process	regulation of myosin-light-chain-phosphatase activity
GO_0007098	Biological process	centrosome cycle
GO_0043086	Biological process	negative regulation of catalytic activity
GO_0046822	Biological process	regulation of nucleocytoplasmic transport
GO_0035508	Biological process	positive regulation of myosin-light-chain-phosphatase activity
GO_1903140	Biological process	regulation of establishment of endothelial barrier
GO_0030155	Biological process	regulation of cell adhesion
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0005886	Cellular component	plasma membrane
GO_0030018	Cellular component	Z disc
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0043292	Cellular component	contractile muscle fiber
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0031672	Cellular component	A band
GO_0005737	Cellular component	cytoplasm
GO_0072357	Cellular component	PTW/PP1 phosphatase complex
GO_0004857	Molecular function	enzyme inhibitor activity
GO_0019901	Molecular function	protein kinase binding
GO_0071889	Molecular function	14-3-3 protein binding
GO_0005515	Molecular function	protein binding
GO_0019208	Molecular function	phosphatase regulator activity

IV. Literature review

[source]

Gene name	PPP1R12A
Protein name	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Protein phosphatase 1 regulatory subunit 12A
Synonyms	MBS MYPT1
Description	FUNCTION: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. .
Accessions	O14974 ENST00000261207.9 [O14974-1] ENST00000550107.5 [O14974-3] H0YHL8 H0YIS3 ENST00000548318.1 ENST00000650220.1 ENST00000634739.1 ENST00000550903.5 A0A0U1RQZ1 ENST00000546369.5 [O14974-5] ENST00000437004.6 [O14974-2] F8VZN8 ENST00000550510.5 H0YIL7 H0YHI8 H0YIS4 ENST00000553081.5 ENST00000547131.1 ENST00000550299.5 ENST00000450142.7 [O14974-1] A0A3B3ISH4 F8VW28 ENST00000546762.5 H0YIM2 ENST00000547330.5

PPP1R12A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review