ARPC1B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	44 studies	63% ± 22%	Explore
B cell	39 studies	48% ± 19%	Explore
natural killer cell	37 studies	54% ± 17%	Explore
endothelial cell	36 studies	43% ± 19%	Explore
CD8-positive, alpha-beta T cell	35 studies	54% ± 21%	Explore
T cell	34 studies	47% ± 22%	Explore
dendritic cell	29 studies	59% ± 27%	Explore
CD4-positive, alpha-beta T cell	29 studies	55% ± 20%	Explore
classical monocyte	27 studies	75% ± 15%	Explore
conventional dendritic cell	27 studies	83% ± 13%	Explore
regulatory T cell	27 studies	61% ± 19%	Explore
fibroblast	25 studies	29% ± 14%	Explore
non-classical monocyte	25 studies	82% ± 16%	Explore
plasmacytoid dendritic cell	24 studies	69% ± 19%	Explore
monocyte	23 studies	63% ± 24%	Explore
mature NK T cell	20 studies	52% ± 11%	Explore
gamma-delta T cell	19 studies	48% ± 18%	Explore
memory B cell	19 studies	54% ± 14%	Explore
naive B cell	19 studies	41% ± 15%	Explore
myeloid cell	18 studies	54% ± 23%	Explore
mast cell	17 studies	33% ± 10%	Explore
endothelial cell of lymphatic vessel	16 studies	52% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	41% ± 12%	Explore
pericyte	16 studies	30% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	45% ± 15%	Explore
mucosal invariant T cell	15 studies	48% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	54% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	56% ± 15%	Explore
capillary endothelial cell	13 studies	32% ± 9%	Explore
plasma cell	12 studies	45% ± 20%	Explore
basal cell	12 studies	36% ± 20%	Explore
vein endothelial cell	12 studies	47% ± 14%	Explore
ciliated cell	12 studies	33% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	41% ± 18%	Explore
platelet	11 studies	69% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	50% ± 24%	Explore
endothelial cell of vascular tree	11 studies	49% ± 15%	Explore
epithelial cell	11 studies	39% ± 17%	Explore
smooth muscle cell	10 studies	23% ± 6%	Explore
plasmablast	10 studies	51% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	53% ± 25%	Explore
neutrophil	10 studies	42% ± 18%	Explore
endothelial cell of artery	10 studies	47% ± 16%	Explore
abnormal cell	9 studies	31% ± 12%	Explore
T follicular helper cell	9 studies	55% ± 18%	Explore
alveolar macrophage	8 studies	62% ± 26%	Explore
innate lymphoid cell	8 studies	45% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	59% ± 26%	Explore
leukocyte	8 studies	57% ± 17%	Explore
mononuclear phagocyte	8 studies	59% ± 28%	Explore
microglial cell	8 studies	45% ± 16%	Explore
type I pneumocyte	7 studies	38% ± 10%	Explore
secretory cell	7 studies	38% ± 22%	Explore
type II pneumocyte	6 studies	41% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	63% ± 27%	Explore
megakaryocyte	6 studies	75% ± 24%	Explore
enterocyte	6 studies	31% ± 14%	Explore
hematopoietic stem cell	6 studies	49% ± 22%	Explore
glial cell	6 studies	49% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	57% ± 26%	Explore
CD4-positive helper T cell	5 studies	45% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	48% ± 7%	Explore
hematopoietic precursor cell	5 studies	56% ± 22%	Explore
exhausted T cell	5 studies	67% ± 24%	Explore
precursor B cell	5 studies	40% ± 15%	Explore
progenitor cell	5 studies	43% ± 24%	Explore
immature B cell	5 studies	58% ± 12%	Explore
double negative thymocyte	5 studies	53% ± 10%	Explore
intermediate monocyte	5 studies	85% ± 8%	Explore
granulocyte	5 studies	37% ± 18%	Explore
connective tissue cell	5 studies	34% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	46% ± 3%	Explore
goblet cell	4 studies	31% ± 15%	Explore
transit amplifying cell	4 studies	24% ± 8%	Explore
lymphocyte	4 studies	52% ± 25%	Explore
club cell	4 studies	26% ± 14%	Explore
germinal center B cell	4 studies	71% ± 14%	Explore
enteroendocrine cell	4 studies	30% ± 9%	Explore
group 3 innate lymphoid cell	4 studies	56% ± 15%	Explore
T-helper 17 cell	4 studies	72% ± 15%	Explore
T-helper 1 cell	4 studies	66% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	76% ± 19%	Explore
respiratory goblet cell	3 studies	24% ± 8%	Explore
pancreatic A cell	3 studies	53% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	77% ± 28%	Explore
glomerular endothelial cell	3 studies	20% ± 2%	Explore
thymocyte	3 studies	34% ± 19%	Explore
extravillous trophoblast	3 studies	81% ± 11%	Explore
placental villous trophoblast	3 studies	75% ± 28%	Explore
common myeloid progenitor	3 studies	57% ± 26%	Explore
pro-B cell	3 studies	27% ± 6%	Explore
Schwann cell	3 studies	39% ± 21%	Explore
adventitial cell	3 studies	35% ± 7%	Explore
mesothelial cell	3 studies	31% ± 14%	Explore
tissue-resident macrophage	3 studies	60% ± 23%	Explore
intraepithelial lymphocyte	3 studies	68% ± 6%	Explore
inflammatory macrophage	3 studies	62% ± 17%	Explore
pancreatic ductal cell	3 studies	53% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	43% ± 31%	Explore
brush cell	3 studies	25% ± 8%	Explore
melanocyte	3 studies	31% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	47% ± 3%	Explore
erythrocyte	3 studies	31% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	54% ± 16%	Explore
lung	17 studies	42% ± 18%	Explore
intestine	10 studies	28% ± 8%	Explore
kidney	7 studies	33% ± 16%	Explore
lymph node	6 studies	47% ± 20%	Explore
bone marrow	5 studies	32% ± 21%	Explore
liver	5 studies	42% ± 18%	Explore
placenta	4 studies	58% ± 26%	Explore
uterus	4 studies	43% ± 13%	Explore
pancreas	3 studies	48% ± 18%	Explore
brain	3 studies	45% ± 14%	Explore
breast	3 studies	28% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	93%	5125.15	1688 / 1809	89%	2.72	418 / 472
esophagus	97%	3825.46	1407 / 1445	82%	2.01	150 / 183
stomach	97%	3232.43	347 / 359	76%	1.73	218 / 286
intestine	100%	6212.69	966 / 966	65%	1.47	345 / 527
lung	100%	10813.97	578 / 578	60%	1.15	692 / 1155
pancreas	75%	1811.48	247 / 328	79%	1.45	140 / 178
bladder	100%	5050.29	21 / 21	49%	0.97	247 / 504
ovary	62%	1464.24	111 / 180	82%	1.81	351 / 430
uterus	99%	3935.84	169 / 170	35%	0.53	159 / 459
kidney	99%	4816.84	88 / 89	33%	0.59	301 / 901
breast	100%	6033.44	459 / 459	24%	0.36	271 / 1118
thymus	100%	5994.85	652 / 653	14%	0.18	86 / 605
adrenal gland	100%	4299.81	257 / 258	3%	0.03	6 / 230
prostate	100%	4346.77	244 / 245	2%	0.02	9 / 502
adipose	100%	7446.14	1204 / 1204	0%	0	0 / 0
peripheral blood	100%	29600.57	929 / 929	0%	0	0 / 0
spleen	100%	18423.10	241 / 241	0%	0	0 / 0
blood vessel	100%	6336.94	1330 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	3.13	28 / 29
heart	93%	2757.35	799 / 861	0%	0	0 / 0
liver	78%	2634.03	177 / 226	13%	0.21	53 / 406
tonsil	0%	0	0 / 0	33%	0.43	15 / 45
brain	26%	515.82	685 / 2642	6%	0.10	45 / 705
eye	0%	0	0 / 0	28%	0.37	22 / 80
muscle	11%	187.18	89 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_0032355	Biological process	response to estradiol
GO_0043627	Biological process	response to estrogen
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0036284	Cellular component	tubulobulbar complex
GO_0005829	Cellular component	cytosol
GO_0005925	Cellular component	focal adhesion
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARPC1B
Protein name	Actin related protein 2/3 complex subunit 1B Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) Actin-related protein 2/3 complex subunit 1B Alternative protein ARPC1B Actin-related protein 2/3 complex subunit
Synonyms	hCG_19475 tcag7.662 ARC41
Description	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . . FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. .
Accessions	ENST00000645391.1 L8EAG6 ENST00000429246.6 C9JTT6 A4D275 ENST00000431816.6 C9JM51 C9JEY1 ENST00000451682.5 ENST00000427217.6 ENST00000417330.6 ENST00000455009.6 ENST00000443222.6 O15143 ENST00000414376.6 ENST00000414376.5 F8VXW2 ENST00000432343.1 ENST00000646101.2 C9JBJ7 ENST00000418347.6 C9K057 ENST00000458033.6

ARPC1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review