RPS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006281Biological processDNA repair
GO_1905053Biological processpositive regulation of base-excision repair
GO_0051301Biological processcell division
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_2001272Biological processpositive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045738Biological processnegative regulation of DNA repair
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0006412Biological processtranslation
GO_0010628Biological processpositive regulation of gene expression
GO_0042981Biological processregulation of apoptotic process
GO_0051225Biological processspindle assembly
GO_0032079Biological processpositive regulation of endodeoxyribonuclease activity
GO_0061481Biological processresponse to TNF agonist
GO_0007059Biological processchromosome segregation
GO_0045739Biological processpositive regulation of DNA repair
GO_0006413Biological processtranslational initiation
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0017148Biological processnegative regulation of translation
GO_0002181Biological processcytoplasmic translation
GO_0043507Biological processpositive regulation of JUN kinase activity
GO_1902231Biological processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0034614Biological processcellular response to reactive oxygen species
GO_0006974Biological processDNA damage response
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0006915Biological processapoptotic process
GO_0006284Biological processbase-excision repair
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005840Cellular componentribosome
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0072686Cellular componentmitotic spindle
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0022626Cellular componentcytosolic ribosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0071159Cellular componentNF-kappaB complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0032587Cellular componentruffle membrane
GO_0022627Cellular componentcytosolic small ribosomal subunit
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0051879Molecular functionHsp90 protein binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0051018Molecular functionprotein kinase A binding
GO_0051536Molecular functioniron-sulfur cluster binding
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0019900Molecular functionkinase binding
GO_0097100Molecular functionsupercoiled DNA binding
GO_0030544Molecular functionHsp70 protein binding
GO_0032357Molecular functionoxidized purine DNA binding
GO_0019899Molecular functionenzyme binding
GO_0003729Molecular functionmRNA binding
GO_0032358Molecular functionoxidized pyrimidine DNA binding
GO_0003723Molecular functionRNA binding
GO_0044390Molecular functionubiquitin-like protein conjugating enzyme binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0140078Molecular functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0019104Molecular functionDNA N-glycosylase activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0015631Molecular functiontubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0008017Molecular functionmicrotubule binding
GO_0004520Molecular functionDNA endonuclease activity
GO_0070181Molecular functionsmall ribosomal subunit rRNA binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRPS3
Protein nameRibosomal protein S3
40S ribosomal protein S3
Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3)
Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18)
SynonymsOK/SW-cl.26
DescriptionFUNCTION: Component of the small ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell . Has endonuclease activity and plays a role in repair of damaged DNA . Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA . Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) . Has also been shown to bind with similar affinity to intact and damaged DNA . Stimulates the N-glycosylase activity of the base excision protein OGG1 . Enhances the uracil excision activity of UNG1 . Also stimulates the cleavage of the phosphodiester backbone by APEX1 . When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage . Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide . Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes . Represses its own translation by binding to its cognate mRNA . Binds to and protects TP53/p53 from MDM2-mediated ubiquitination . Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization . Involved in induction of apoptosis through its role in activation of CASP8 . Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 . Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation . .

AccessionsENST00000527446.5 [P23396-1]
ENST00000525933.1
E9PSF4
ENST00000525690.1
P23396
ENST00000530164.5
ENST00000422465.6
ENST00000527273.5
H0YES8
ENST00000528439.5
ENST00000528847.1
ENST00000534440.5
ENST00000524851.5 [P23396-1]
ENST00000278572.10 [P23396-2]
A7E2S3
E9PQ96
Q9NQS8
ENST00000526248.5
ENST00000526608.5
E9PJH4
E9PK82
ENST00000532872.5
H0YF32
H0YCJ7
E9PPU1
E9PL09
E9PJN9
ENST00000530170.1
ENST00000531188.6 [P23396-1]
ENST00000530721.5
H0YEU2
E9PQX2
F2Z2S8