TNFSF13B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0042098Biological processT cell proliferation
GO_0002467Biological processgerminal center formation
GO_0007165Biological processsignal transduction
GO_0031295Biological processT cell costimulation
GO_0001782Biological processB cell homeostasis
GO_0002333Biological processtransitional one stage B cell differentiation
GO_0031296Biological processB cell costimulation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0042100Biological processB cell proliferation
GO_0043588Biological processskin development
GO_0002636Biological processpositive regulation of germinal center formation
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0048018Molecular functionreceptor ligand activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameTNFSF13B
Protein nameTumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
B-lymphocyte stimulator
SynonymsBAFF
TALL1
ZTNF4
BLYS
UNQ401/PRO738
TNFSF20
DescriptionFUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. .; FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. .; FUNCTION: [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. .

AccessionsENST00000375887.9 [Q9Y275-1]
ENST00000430559.5 [Q9Y275-2]
Q8IZI4
ENST00000542136.1 [Q9Y275-3]
Q8IZI5
Q9Y275
Q8IZI6