SLC4A2 | OmnibusX

Name	Number of supported studies	Average coverage
retinal pigment epithelial cell	5 studies	38% ± 18%	Explore
epithelial cell	3 studies	37% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC4A2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	4824.83	180 / 180	100%	48.83	429 / 430
skin	100%	4035.68	1809 / 1809	100%	87.94	470 / 472
esophagus	100%	4453.15	1445 / 1445	99%	33.04	182 / 183
intestine	100%	5647.41	966 / 966	99%	42.50	523 / 527
stomach	100%	9021.70	359 / 359	99%	44.22	283 / 286
lung	100%	5348.54	578 / 578	98%	34.28	1133 / 1155
kidney	100%	5005.21	89 / 89	98%	37.98	883 / 901
pancreas	100%	4300.44	328 / 328	98%	33.39	174 / 178
breast	100%	3935.82	459 / 459	97%	32.49	1088 / 1118
uterus	100%	6315.81	170 / 170	97%	30.88	444 / 459
bladder	100%	4810.14	21 / 21	96%	31.08	485 / 504
prostate	100%	4489.58	245 / 245	96%	28.67	483 / 502
thymus	100%	4270.75	652 / 653	95%	23.11	576 / 605
liver	100%	3881.65	226 / 226	93%	34.54	379 / 406
brain	84%	1216.26	2212 / 2642	98%	31.08	690 / 705
adrenal gland	100%	4964.92	258 / 258	80%	16.26	184 / 230
adipose	100%	4123.94	1204 / 1204	0%	0	0 / 0
spleen	100%	3895.22	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.81	1 / 1
blood vessel	100%	4742.45	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	52.64	79 / 80
heart	98%	2982.67	844 / 861	0%	0	0 / 0
muscle	97%	1591.57	782 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	25.12	43 / 45
peripheral blood	93%	1901.49	862 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	14.16	22 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007283	Biological process	spermatogenesis
GO_0030316	Biological process	osteoclast differentiation
GO_0055085	Biological process	transmembrane transport
GO_0045124	Biological process	regulation of bone resorption
GO_0043377	Biological process	negative regulation of CD8-positive, alpha-beta T cell differentiation
GO_0006820	Biological process	monoatomic anion transport
GO_1902476	Biological process	chloride transmembrane transport
GO_0048565	Biological process	digestive tract development
GO_0070175	Biological process	positive regulation of enamel mineralization
GO_2000565	Biological process	negative regulation of CD8-positive, alpha-beta T cell proliferation
GO_0051453	Biological process	regulation of intracellular pH
GO_0015701	Biological process	bicarbonate transport
GO_0097186	Biological process	amelogenesis
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005925	Cellular component	focal adhesion
GO_0016323	Cellular component	basolateral plasma membrane
GO_0019899	Molecular function	enzyme binding
GO_0008509	Molecular function	monoatomic anion transmembrane transporter activity
GO_0140900	Molecular function	chloride:bicarbonate antiporter activity
GO_0005452	Molecular function	solute:inorganic anion antiporter activity
GO_0022857	Molecular function	transmembrane transporter activity

Gene name	SLC4A2
Protein name	Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) Solute carrier family 4 member 2 Anion exchange protein
Synonyms	AE2 MPB3L EPB3L1 HKB3
Description	FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane . Plays an important role in osteoclast differentiation and function . Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). .
Accessions	C9JVC2 ENST00000463414.5 P04920 C9J722 ENST00000461735.1 [P04920-2] ENST00000490898.5 Q9UEY4 Q6PJY3 C9J9M9 ENST00000485713.5 [P04920-1] ENST00000482950.5 Q8TAG3 C9J035 ENST00000483786.5 ENST00000392826.6 [P04920-3] A0A7I2V5T6 ENST00000488420.1 Q99654 Q9UEY5 Q9UEY6 C9J459 ENST00000677246.1 ENST00000413384.7 [P04920-1]

SLC4A2 report