CLTC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031623Biological processreceptor internalization
GO_0000278Biological processmitotic cell cycle
GO_0006898Biological processreceptor-mediated endocytosis
GO_0001649Biological processosteoblast differentiation
GO_0006886Biological processintracellular protein transport
GO_0051301Biological processcell division
GO_0072318Biological processclathrin coat disassembly
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0048268Biological processclathrin coat assembly
GO_0150093Biological processamyloid-beta clearance by transcytosis
GO_0033572Biological processtransferrin transport
GO_0006914Biological processautophagy
GO_0060236Biological processregulation of mitotic spindle organization
GO_0072583Biological processclathrin-dependent endocytosis
GO_1900126Biological processnegative regulation of hyaluronan biosynthetic process
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_1990498Cellular componentmitotic spindle microtubule
GO_0005886Cellular componentplasma membrane
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0030118Cellular componentclathrin coat
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_1903561Cellular componentextracellular vesicle
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0071439Cellular componentclathrin complex
GO_0005925Cellular componentfocal adhesion
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0030130Cellular componentclathrin coat of trans-Golgi network vesicle
GO_0005829Cellular componentcytosol
GO_0030132Cellular componentclathrin coat of coated pit
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0005768Cellular componentendosome
GO_0042470Cellular componentmelanosome
GO_0005819Cellular componentspindle
GO_0036020Cellular componentendolysosome membrane
GO_0032051Molecular functionclathrin light chain binding
GO_0019901Molecular functionprotein kinase binding
GO_0005198Molecular functionstructural molecule activity
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0003723Molecular functionRNA binding
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameCLTC
Protein nameCLTC protein
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Clathrin heavy chain
SynonymshCG_1818599
CLH17
KIAA0034
CLTCL2
DescriptionFUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge . The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension . Plays a role in early autophagosome formation . Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .

AccessionsA0A8V8TRE8
ENST00000700710.1
K7EJJ5
ENST00000700709.1
ENST00000472651.6
A0A8V8TQK3
A0A8V8TQ18
A0A087WVQ6
ENST00000475458.2
ENST00000700714.1
A0A8V8TQK7
ENST00000580081.2
J3KS13
ENST00000700712.1
ENST00000700711.1
J3KTN1
A0A8V8TQK1
ENST00000579456.5
Q49AL0
ENST00000269122.8 [Q00610-1]
ENST00000584313.5
ENST00000483176.2
ENST00000700713.1
ENST00000700715.1
A0A8V8TR47
ENST00000700707.1 [Q00610-1]
Q00610
J3QL20
J3KRF5
ENST00000700708.1
A0A8V8TQ14
A0A8V8TRF0
ENST00000393043.5 [Q00610-2]