CD46 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071636Biological processpositive regulation of transforming growth factor beta production
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0010629Biological processnegative regulation of gene expression
GO_0043382Biological processpositive regulation of memory T cell differentiation
GO_0045087Biological processinnate immune response
GO_0035581Biological processsequestering of extracellular ligand from receptor
GO_0010628Biological processpositive regulation of gene expression
GO_0008593Biological processregulation of Notch signaling pathway
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0045959Biological processnegative regulation of complement activation, classical pathway
GO_0002250Biological processadaptive immune response
GO_0046718Biological processsymbiont entry into host cell
GO_0006958Biological processcomplement activation, classical pathway
GO_0007338Biological processsingle fertilization
GO_0002456Biological processT cell mediated immunity
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0002079Cellular componentinner acrosomal membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0045296Molecular functioncadherin binding
GO_0001618Molecular functionvirus receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD46
Protein nameMembrane cofactor protein
Complement system membrane cofactor protein CD46
Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)
CD46 molecule
SynonymsMIC10
MCP
hCG_1987002
DescriptionFUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .; FUNCTION: (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; FUNCTION: (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. .; FUNCTION: (Microbial infection) Acts as a receptor for cultured Measles virus. .; FUNCTION: (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. .; FUNCTION: (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. .

AccessionsP15529
ENST00000367042.6 [P15529-11]
ENST00000695778.1
ENST00000480003.5 [P15529-6]
ENST00000367041.5 [P15529-12]
ENST00000322918.9 [P15529-9]
ENST00000360212.6 [P15529-7]
ENST00000357714.5 [P15529-4]
ENST00000462968.2
A0A8Q3WKW1
A0A8Q3WKS6
ENST00000358170.6 [P15529-1]
ENST00000367047.5 [P15529-16]
ENST00000695777.1
ENST00000695782.1
ENST00000695781.1
A0A8Q3WLA6
ENST00000354848.5 [P15529-3]
ENST00000695780.1
ENST00000695784.1
R4GN18
Q06C42
A0A8Q3WLU6
A0A8Q3WKR0
A0A8Q3WKR4
ENST00000322875.8 [P15529-2]