TM4SF20 | OmnibusX

Name	Number of supported studies	Average coverage
enterocyte	6 studies	42% ± 11%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TM4SF20 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	69%	1503.33	664 / 966	74%	20.20	390 / 527
stomach	35%	3.01	126 / 359	74%	20.69	213 / 286
pancreas	47%	3.06	153 / 328	43%	18.99	76 / 178
spleen	80%	7.22	193 / 241	0%	0	0 / 0
esophagus	25%	4.11	368 / 1445	44%	26.51	80 / 183
brain	61%	7.35	1620 / 2642	1%	0.01	4 / 705
liver	35%	2.27	80 / 226	25%	12.35	101 / 406
adrenal gland	58%	4.53	150 / 258	0%	0	0 / 230
adipose	55%	6.21	658 / 1204	0%	0	0 / 0
kidney	52%	3.91	46 / 89	1%	0.04	9 / 901
bladder	29%	1.81	6 / 21	20%	2.99	99 / 504
lung	30%	2.31	175 / 578	13%	7.10	151 / 1155
thymus	43%	3.32	279 / 653	0%	0	0 / 605
breast	42%	4.23	191 / 459	0%	0.00	1 / 1118
prostate	39%	2.57	96 / 245	2%	0.10	10 / 502
skin	36%	25.08	656 / 1809	1%	0.06	5 / 472
uterus	35%	4.51	59 / 170	3%	1.60	12 / 459
peripheral blood	35%	3.32	325 / 929	0%	0	0 / 0
ovary	29%	2.32	53 / 180	0%	0	0 / 430
blood vessel	18%	1.21	238 / 1335	0%	0	0 / 0
heart	12%	0.70	104 / 861	0%	0	0 / 0
muscle	10%	0.56	81 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045861	Biological process	negative regulation of proteolysis
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005925	Cellular component	focal adhesion
GO_0005515	Molecular function	protein binding

Gene name	TM4SF20
Protein name	Transmembrane 4 L6 family member 20 Transmembrane 4 L six family member 20
Synonyms	UNQ518/PRO994
Description	FUNCTION: Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis . In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 . Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein . .
Accessions	Q53R12 C9JES4 ENST00000449706.1 ENST00000304568.4

TM4SF20 report